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Literature summary for 1.1.1.21 extracted from

  • Lee, Y.S.; Kim, S.H.; Jung, S.H.; Kim, J.K.; Pan, C.H.; Lim, S.S.
    Aldose reductase inhibitory compounds from Glycyrrhiza uralensis (2010), Biol. Pharm. Bull., 33, 917-921.
    View publication on PubMed
Search for more literature for 1.1.1.21

Inhibitors

Inhibitors Comment Organism Structure
(2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
-
 Homo sapiens
(2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
-
 Rattus norvegicus
3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one a gamma,gamma-dimethylallyl type prenylated isoflavonoid Homo sapiens
3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one a gamma,gamma-dimethylallyl type prenylated isoflavonoid Rattus norvegicus
3-[3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one a gamma,gamma-dimethylallyl type prenylated isoflavonoid Homo sapiens
3-[3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one a gamma,gamma-dimethylallyl type prenylated isoflavonoid Rattus norvegicus
4-[5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol a gamma,gamma-dimethylallyl type prenylated isoflavonoid Homo sapiens
4-[5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol a gamma,gamma-dimethylallyl type prenylated isoflavonoid Rattus norvegicus
4-[7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol a gamma,gamma-dimethylallyl type prenylated isoflavonoid Homo sapiens
4-[7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol a gamma,gamma-dimethylallyl type prenylated isoflavonoid Rattus norvegicus
epalrestat
-
 Homo sapiens
epalrestat
-
 Rattus norvegicus
isoliquiritigenin
-
 Homo sapiens
isoliquiritigenin
-
 Rattus norvegicus
liquiritigenin
-
 Homo sapiens
liquiritigenin
-
 Rattus norvegicus
additional information identification of inhibitory compounds from Glycyrrhiza uralensis, overview Homo sapiens
additional information identification of inhibitory compounds from Glycyrrhiza uralensis, overview. Inhibitory effect of the compounds on the sorbitol accumulation in rat lenses incubated with high glucose Rattus norvegicus
Myricitrin
-
 Homo sapiens
Myricitrin
-
 Rattus norvegicus
quercetin
-
 Homo sapiens
quercetin
-
 Rattus norvegicus
quercitrin
-
 Homo sapiens
quercitrin
-
 Rattus norvegicus
semilicoisoflavone B contains a gamma,gamma-dimethylchromene ring on the aromatic ring Homo sapiens
semilicoisoflavone B contains a gamma,gamma-dimethylchromene ring on the aromatic ring Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DL-glyceraldehyde + NADPH + H+ Homo sapiens
-
 DL-glycerol + NADP+
-
 ?
DL-glyceraldehyde + NADPH + H+ Rattus norvegicus
-
 DL-glycerol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant enzyme Homo sapiens
-
lens
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-glyceraldehyde + NADPH + H+
-
 Homo sapiens DL-glycerol + NADP+
-
 ?
DL-glyceraldehyde + NADPH + H+
-
 Rattus norvegicus DL-glycerol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
aldose reductase
-
 Homo sapiens
aldose reductase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2
-
 assay at Homo sapiens
7
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens
NADPH
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0018
-
 pH 7.0, 37°C Rattus norvegicus semilicoisoflavone B
0.002
-
 pH 7.0, 37°C Rattus norvegicus liquiritigenin
0.0025
-
 pH 7.0, 37°C Rattus norvegicus quercetin
0.0034
-
 pH 7.0, 37°C Rattus norvegicus isoliquiritigenin
0.0106
-
 pH 6.2, 37°C Homo sapiens semilicoisoflavone B
0.0127
-
 pH 7.0, 37°C Homo sapiens quercetin
0.0219
-
 pH 7.0, 37°C Homo sapiens liquiritigenin
0.0275
-
 pH 7.0, 37°C Homo sapiens isoliquiritigenin
0.0285
-
 pH 7.0, 37°C Rattus norvegicus 3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
0.0427
-
 pH 7.0, 37°C Rattus norvegicus 4-[7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol
0.0624
-
 pH 7.0, 37°C Rattus norvegicus 4-[5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol
0.0765
-
 pH 7.0, 37°C Homo sapiens 3-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
0.0963
-
 pH 7.0, 37°C Rattus norvegicus (2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
0.0995
-
 pH 7.0, 37°C Rattus norvegicus 3-[3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
0.1306
-
 pH 7.0, 37°C Homo sapiens 4-[7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol
0.1762
-
 pH 7.0, 37°C Homo sapiens 4-[5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2H-chromen-3-yl]benzene-1,3-diol
0.2572
-
 pH 7.0, 37°C Homo sapiens (2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
0.2808
-
 pH 7.0, 37°C Homo sapiens 3-[3,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one