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Literature summary for 1.1.1.21 extracted from

  • Hallam, K.M.; Li, Q.; Ananthakrishnan, R.; Kalea, A.; Zou, Y.S.; Vedantham, S.; Schmidt, A.M.; Yan, S.F.; Ramasamy, R.
    Aldose reductase and AGE-RAGE pathways: central roles in the pathogenesis of vascular dysfunction in aging rats (2010), Aging Cell, 9, 776-784.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.21

Inhibitors

Inhibitors Comment Organism Structure
zopolrestat treatment with the aldose reductase inhibitor zopolrestat significantly improves endothelial-dependent relaxation in response to acetylcholine in aged rats Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Fischer 344 rats
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelium aortic, higher activity in aged compared to young rats Rattus norvegicus
-
smooth muscle cell
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
aldose reductase
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus upregulation of the aldose reductase pathway with aging up

General Information

General Information Comment Organism
physiological function the enzyme and AGE-RAGE pathways, involving advanced glycation endproducts and their a soluble form of the chief signal transduction receptors, play central roles in the pathogenesis of vascular dysfunction in aging rats. Significant increases in aldose reductase expression and activity in aged rat vasculature linked to endothelial dysfunction may be mitigated, at least in part, via aldose reductase inhibitors and that aging-linked increased flux via aldose reductase generates advanced glycation endproducts, species which transduce endothelial injury consequent to their interaction with RAGE, the soluble form of the chief signal transduction receptors of advanced glycation products Rattus norvegicus