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Literature summary for 1.1.1.21 extracted from

  • Reddy, G.B.; Satyanarayana, A.; Balakrishna, N.; Ayyagari, R.; Padma, M.; Viswanath, K.; Petrash, J.M.
    Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy (2008), Mol. Vis., 14, 593-601.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine levels of ALR2 activity as well as sorbitol in erythrocytes may have value as a quantitative trait to establish a risk profile for development of diabetic retinopathy, type 2 diabetic patients with diabetic retinopathy show significantly higher specific activity of ALR2 as compared to type 2 diabetic patients without diabetic retinopathy Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose + NADPH + H+
-
Homo sapiens sorbitol + NADP+
-
?

Synonyms

Synonyms Comment Organism
aldose reductase
-
Homo sapiens
ALR2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens