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Literature summary for 1.1.1.21 extracted from

  • Ha, D.T.; Ngoc, T.M.; Lee, I.; Lee, Y.M.; Kim, J.S.; Jung, H.; Lee, S.; Na, M.; Bae, K.
    Inhibitors of aldose reductase and formation of advanced glycation end-products in moutan cortex (Paeonia suffruticosa) (2009), J. Nat. Prod., 72, 1465-1470.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3,3-Tetramethyleneglutaric acid
-
Rattus norvegicus
30-norhederagenin
-
Rattus norvegicus
4-O-butylpaeoniflorin
-
Rattus norvegicus
5-hydroxy-3S-hydroxymethyl-6-methyl-2,3-dihydrobenzofuran
-
Rattus norvegicus
6-methoxypaeoniflorigenone
-
Rattus norvegicus
8-O-benzoylpaeonidanin
-
Rattus norvegicus
alpha-benzoyloxypaeoniflorin
-
Rattus norvegicus
apiopaeonoside
-
Rattus norvegicus
benzoylpaeoniflorin
-
Rattus norvegicus
beta-benzoyloxypaeoniflorin
-
Rattus norvegicus
galloylpaeoniflorin
-
Rattus norvegicus
nudanpinoside H
-
Rattus norvegicus
oxypaeoniflorin
-
Rattus norvegicus
paeoniflorigenone
-
Rattus norvegicus
paeoniflorin
-
Rattus norvegicus
paeonol
-
Rattus norvegicus
paeonolide
-
Rattus norvegicus
paeonoside
-
Rattus norvegicus
palbinone
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-glyceraldehyde + NADPH + H+
-
Rattus norvegicus glycerol + NADP+
-
?

Synonyms

Synonyms Comment Organism
aldose reductase
-
Rattus norvegicus
RLAR
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0114
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus palbinone
0.0288
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus 30-norhederagenin
0.0318
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus 3,3-Tetramethyleneglutaric acid
0.0362
-
in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus 4-O-butylpaeoniflorin
0.0446
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus galloylpaeoniflorin
0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus paeonol
0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus 8-O-benzoylpaeonidanin
0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus 5-hydroxy-3S-hydroxymethyl-6-methyl-2,3-dihydrobenzofuran
0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus paeoniflorin
0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus benzoylpaeoniflorin
0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus oxypaeoniflorin
0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus nudanpinoside H
0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus alpha-benzoyloxypaeoniflorin
0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus beta-benzoyloxypaeoniflorin
0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus paeoniflorigenone
0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus 6-methoxypaeoniflorigenone
0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus paeonolide
0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus paeonoside
0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus apiopaeonoside