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Literature summary for 1.1.1.21 extracted from

  • Lee, S.J.; Park, W.H.; Park, S.D.; Moon, H.I.
    Aldose reductase inhibitors from Litchi chinensis Sonn (2009), J. Enzyme Inhib. Med. Chem., 24, 957-959.
    View publication on PubMed
Search for more literature for 1.1.1.21

Inhibitors

Inhibitors Comment Organism Structure
2,5-dihydrobenzoic acid
-
 Rattus norvegicus
D-mannitol
-
 Rattus norvegicus
delphinidin 3-O-beta-galactopyranoside most potent inhibitor Rattus norvegicus
delphinidin 3-O-beta-galactopyranoside-3',5'-di-O-beta-glucopyranoside
-
 Rattus norvegicus
additional information methanolic and ethanolic extracts of Litchi chinensis fruits are potent inhibitors of rat lens aldose reductase Rattus norvegicus
tetramethylene glutaric acid
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-glyceraldehyde + NADPH + H+
-
 Rattus norvegicus glycerol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
aldose reductase
-
 Rattus norvegicus
ALR
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 D-mannitol IC50: above 0.1 mg/ml, 2,5-dihydrobenzoic acid IC50: 0.0359 mg/ml, delphinidin 3-O-beta-galactopyranoside-3',5'-di-O-beta-glucopyranoside IC50: 0.00123 mg/ml, delphinidin 3-O-beta-galactopyranoside IC50: 0.00023 mg/ml, methanolic and ethanolic extracts of Litchi chinensis fruits are potent inhibitors with IC50 values of 0.0036 and 0.0003 mg/ml, respectively Rattus norvegicus additional information