Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4-hydroxyphenyl)(6-hydroxypyrazin-2-yl)methanone | isolated from red ascidian Botryllus leachi, pyrazine derivative, IC50: 0.0414 mM | Homo sapiens | |
(4-hydroxyphenyl)[4-(4-hydroxyphenyl)-1H-imidazol-2-yl]methanone | isolated from red ascidian Botryllus leachi, imidazole derivative, IC50: 0.0214 mM | Homo sapiens | |
(5Z)-3-chloro-4-(3,5-dibromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one | isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.019 mM | Homo sapiens | |
(5Z)-3-chloro-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(4-hydroxyphenyl)furan-2(5H)-one | isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.0008 mM | Homo sapiens | |
(5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one | isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.020 mM | Homo sapiens | |
(5Z)-4-(3-bromo-4-hydroxyphenyl)-3-chloro-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one | isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.013 mM | Homo sapiens | |
(5Z)-4-(3-bromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one | isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.048 mM | Homo sapiens | |
(5Z)-4-(3-bromo-4-hydroxyphenyl)-5-[(3-bromo-4-hydroxyphenyl)methylidene]-3-chlorofuran-2(5H)-one | isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.017 mM | Homo sapiens | |
(5Z)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(4-hydroxyphenyl)furan-2(5H)-one | isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.057 mM | Homo sapiens | |
(5Z)-5-[(3-bromo-4-hydroxyphenyl)methylidene]-3-chloro-4-(4-hydroxyphenyl)furan-2(5H)-one | isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.046 mM | Homo sapiens | |
epalrestat | orally active inhibitor | Homo sapiens | |
lukianol B | IC50: 0.0006 mM | Homo sapiens | |
sorbinil | orally active inhibitor, IC50: 0.0036 mM | Homo sapiens | |
Tolrestat | orally active inhibitor | Homo sapiens | |
Zenarestat | orally active inhibitor | Homo sapiens | |
[6-hydroxy-3-(4-hydroxyphenoxy)pyrazin-2-yl](4-hydroxyphenyl)methanone | isolated from red ascidian Botryllus leachi, pyrazine derivative, IC50: 0.0194 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
aldose + NADPH + H+ | Homo sapiens | - |
alditol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aldose + NADPH + H+ | - |
Homo sapiens | alditol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Homo sapiens |
ALR2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.2 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0006 | - |
IC50: 0.0006 mM | Homo sapiens | lukianol B | |
0.0008 | - |
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.0008 mM | Homo sapiens | (5Z)-3-chloro-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(4-hydroxyphenyl)furan-2(5H)-one | |
0.0036 | - |
orally active inhibitor, IC50: 0.0036 mM | Homo sapiens | sorbinil | |
0.013 | - |
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.013 mM | Homo sapiens | (5Z)-4-(3-bromo-4-hydroxyphenyl)-3-chloro-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one | |
0.017 | - |
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.017 mM | Homo sapiens | (5Z)-4-(3-bromo-4-hydroxyphenyl)-5-[(3-bromo-4-hydroxyphenyl)methylidene]-3-chlorofuran-2(5H)-one | |
0.019 | - |
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.019 mM | Homo sapiens | (5Z)-3-chloro-4-(3,5-dibromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one | |
0.0194 | - |
isolated from red ascidian Botryllus leachi, pyrazine derivative, IC50: 0.0194 mM | Homo sapiens | [6-hydroxy-3-(4-hydroxyphenoxy)pyrazin-2-yl](4-hydroxyphenyl)methanone | |
0.02 | - |
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.020 mM | Homo sapiens | (5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one | |
0.0214 | - |
isolated from red ascidian Botryllus leachi, imidazole derivative, IC50: 0.0214 mM | Homo sapiens | (4-hydroxyphenyl)[4-(4-hydroxyphenyl)-1H-imidazol-2-yl]methanone | |
0.0414 | - |
isolated from red ascidian Botryllus leachi, pyrazine derivative, IC50: 0.0414 mM | Homo sapiens | (4-hydroxyphenyl)(6-hydroxypyrazin-2-yl)methanone | |
0.046 | - |
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.046 mM | Homo sapiens | (5Z)-5-[(3-bromo-4-hydroxyphenyl)methylidene]-3-chloro-4-(4-hydroxyphenyl)furan-2(5H)-one | |
0.048 | - |
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.048 mM | Homo sapiens | (5Z)-4-(3-bromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2(5H)-one | |
0.057 | - |
isolated from ascidians Ritterella rubra and Synoicum blochmanni, IC50: 0.057 mM | Homo sapiens | (5Z)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(4-hydroxyphenyl)furan-2(5H)-one |