Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,5-bis(3,4-dihydroxyphenyl)-1,4-pentadiene-3-one | IC50: 0.0034 mM | Bos taurus | |
1,5-bis(3,5-di-tert-butyl-4-hydroxyphenyl)-1,4-pentadiene-3-one | 31.0% inhibition at 0.1 mM | Bos taurus | |
1,5-bis(4-hydroxy-3,5-dimethoxyphenyl)-1,4-pentadiene-3-one | IC50: 0.0253 mM | Bos taurus | |
1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadiene-3-one | IC50: 0.0359 mM | Bos taurus | |
1,5-bis(4-hydroxyphenyl)-1,4-pentadiene-3-one | IC50: 0.0331 mM | Bos taurus | |
2,5-bis(3,4-dihydroxybenzylidene)cyclopentanone | IC50: 0.0026 mM | Bos taurus | |
2,5-bis(3,5-di-tert-butyl-4-hydroxybenzylidene)cyclopentanone | 38.2% inhibition at 0.1 mM | Bos taurus | |
2,5-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)cyclopentanone | IC50: 0.0208 mM | Bos taurus | |
2,5-bis(4-hydroxy-3,5-dimethoxybenzylidene)cyclopentanone | IC50: 0.0234 mM | Bos taurus | |
2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone | IC50: 0.0258 mM | Bos taurus | |
2,5-bis(4-hydroxybenzylidene)cyclopentanone | IC50: 0.0274 mM | Bos taurus | |
2,6-bis(3,4-dihydroxybenzylidene)cyclohexanone | IC50: 0.0029 mM | Bos taurus | |
2,6-bis(3,5-di-tert-butyl-4-hydroxybenzylidene)cyclohexanone | 35.8% inhibition at 0.1 mM | Bos taurus | |
2,6-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)cyclohexanone | IC50: 0.021 mM | Bos taurus | |
2,6-bis(4-hydroxy-3,5-dimethoxybenzylidene)cyclohexanone | IC50: 0.0249 mM | Bos taurus | |
2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone | IC50: 0.0264 mM | Bos taurus | |
2,6-bis(4-hydroxybenzylidene)cyclohexanone | IC50: 0.0275 mM | Bos taurus | |
3,5-bis(3,4-dihydroxybenzylidene)-4-piperidone | IC50: 0.0049 mM | Bos taurus | |
3,5-bis(3,5-di-tert-butyl-4-hydroxybenzylidene)-4-piperidone | 29.2% inhibition at 0.1 mM | Bos taurus | |
3,5-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)-4-piperidone | IC50: 0.0208 mM | Bos taurus | |
3,5-bis(4-hydroxy-3,5-dimethoxybenzylidene)-4-piperidone | IC50: 0.0223 mM | Bos taurus | |
3,5-bis(4-hydroxy-3-methoxybenzylidene)-4-piperidone | IC50: 0.0299 mM | Bos taurus | |
3,5-bis(4-hydroxyphenyl)-4-piperidone | IC50: 0.0311 mM | Bos taurus | |
bisdemethoxycurcumin | i.e. 1,7-bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione, extracted from Curcuma longa roots, IC50: 0.0137 mM | Bos taurus | |
curcumin | i.e. 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, extracted from Curcuma longa roots, IC50: 0.0068 mM | Bos taurus | |
demethoxycurcumin | i.e. 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione, extracted from Curcuma longa roots, IC50: 0.0159 mM | Bos taurus | |
additional information | no inhibition by 3,5-bis(3,4-dimethoxybenzylidene)-4-piperidone, 1,5-bis(3,4-dimethoxyphenyl)-1,4-pentadiene-3-one, 2,5-bis(3,4-dimethoxybenzylidene)cyclopentanone, and 2,6-bis(3,4-dimethoxybenzylidene)cyclohexanone, at 0.1 mM | Bos taurus | |
quercetin | IC50: 0.0376 mM | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lens | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glyceraldehyde + NADPH + H+ | - |
Bos taurus | glycerol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Bos taurus |
ALR2 | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
assay at | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0026 | - |
IC50: 0.0026 mM | Bos taurus | 2,5-bis(3,4-dihydroxybenzylidene)cyclopentanone | |
0.0029 | - |
IC50: 0.0029 mM | Bos taurus | 2,6-bis(3,4-dihydroxybenzylidene)cyclohexanone | |
0.0034 | - |
IC50: 0.0034 mM | Bos taurus | 1,5-bis(3,4-dihydroxyphenyl)-1,4-pentadiene-3-one | |
0.0049 | - |
IC50: 0.0049 mM | Bos taurus | 3,5-bis(3,4-dihydroxybenzylidene)-4-piperidone | |
0.0068 | - |
i.e. 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, extracted from Curcuma longa roots, IC50: 0.0068 mM | Bos taurus | curcumin | |
0.0137 | - |
i.e. 1,7-bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione, extracted from Curcuma longa roots, IC50: 0.0137 mM | Bos taurus | bisdemethoxycurcumin | |
0.0159 | - |
i.e. 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione, extracted from Curcuma longa roots, IC50: 0.0159 mM | Bos taurus | demethoxycurcumin | |
0.0208 | - |
IC50: 0.0208 mM | Bos taurus | 2,5-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)cyclopentanone | |
0.0208 | - |
IC50: 0.0208 mM | Bos taurus | 3,5-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)-4-piperidone | |
0.021 | - |
IC50: 0.021 mM | Bos taurus | 2,6-bis(3-bromo-4-hydroxy-5-methoxybenzylidene)cyclohexanone | |
0.0223 | - |
IC50: 0.0223 mM | Bos taurus | 3,5-bis(4-hydroxy-3,5-dimethoxybenzylidene)-4-piperidone | |
0.0234 | - |
IC50: 0.0234 mM | Bos taurus | 2,5-bis(4-hydroxy-3,5-dimethoxybenzylidene)cyclopentanone | |
0.0249 | - |
IC50: 0.0249 mM | Bos taurus | 2,6-bis(4-hydroxy-3,5-dimethoxybenzylidene)cyclohexanone | |
0.0253 | - |
IC50: 0.0253 mM | Bos taurus | 1,5-bis(4-hydroxy-3,5-dimethoxyphenyl)-1,4-pentadiene-3-one | |
0.0258 | - |
IC50: 0.0258 mM | Bos taurus | 2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone | |
0.0264 | - |
IC50: 0.0264 mM | Bos taurus | 2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone | |
0.0274 | - |
IC50: 0.0274 mM | Bos taurus | 2,5-bis(4-hydroxybenzylidene)cyclopentanone | |
0.0275 | - |
IC50: 0.0275 mM | Bos taurus | 2,6-bis(4-hydroxybenzylidene)cyclohexanone | |
0.0299 | - |
IC50: 0.0299 mM | Bos taurus | 3,5-bis(4-hydroxy-3-methoxybenzylidene)-4-piperidone | |
0.0311 | - |
IC50: 0.0311 mM | Bos taurus | 3,5-bis(4-hydroxyphenyl)-4-piperidone | |
0.0331 | - |
IC50: 0.0331 mM | Bos taurus | 1,5-bis(4-hydroxyphenyl)-1,4-pentadiene-3-one | |
0.0359 | - |
IC50: 0.0359 mM | Bos taurus | 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadiene-3-one | |
0.0376 | - |
IC50: 0.0376 mM | Bos taurus | quercetin |