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Literature summary for 1.1.1.21 extracted from

  • Dal Monte, M.; Del Corso, A.; Moschini, R.; Cappiello, M.; Amodeo, P.; Mura, U.
    Zofenoprilat-glutathione mixed disulfide as a specific S-thiolating agent of bovine lens aldose reductase (2005), Antioxid. Redox Signal., 7, 841-848.
    View publication on PubMed
Search for more literature for 1.1.1.21

General Stability

General Stability Organism
DTT stabilizes the purified native enzyme from lens at 2 mM Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
zofenoprilat-glutathione disulfide the enzyme is specifically S-thionylated and inactivated by ZSSG, a homodisulfide formed by GSH and zofenoprilat, an angiotensin-converting enzyme inhibitor carrying a thiol group, which is more stable than glutathione, optimization, overview Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.92
-
 purified native enzyme from lens Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glyceraldehyde + NADPH + H+
-
 Bos taurus glycerol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
aldose reductase
-
 Bos taurus
ALR2
-
 Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Bos taurus

pI Value

Organism Comment pI Value Maximum pI Value
Bos taurus isoelectric focusing 4.9 4.8