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Literature summary for 1.1.1.21 extracted from

  • Sotriffer, C.A.; Kramer, O.; Klebe, G.
    Probing flexibility and "induced-fit" phenomena in aldose reductase by comparative crystal structure analysis and molecular dynamics simulations (2004), Proteins, 56, 52-66.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
C298A/W219Y protein data bank: 1az1, structural analysis by molecular dynamics simulations Homo sapiens
Y48H protein data bank: 2acu, structural analysis by molecular dynamics simulations Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
IDD594
-
Homo sapiens
IDD594
-
Sus scrofa
sorbinil
-
Homo sapiens
sorbinil
-
Sus scrofa
Tolrestat
-
Homo sapiens
Tolrestat
-
Sus scrofa
Zenarestat
-
Homo sapiens
Zenarestat
-
Sus scrofa

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Subunits

Subunits Comment Organism
More structural analysis by molecular dynamics simulations, highly conserved confomations around the catalytic site with H110-Y48-NADP+ orientation stabilized by a water molecule Homo sapiens
More structural analysis by molecular dynamics simulations, highly conserved confomations around the catalytic site with H110-Y48-NADP+ orientation stabilized by a water molecule Sus scrofa