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Literature summary for 1.1.1.21 extracted from

  • Negm, F.B.
    Purification and properties of an NADPH-aldose reductase (aldehyde reductase) from Euonymus japonica leaves (1986), Plant Physiol., 80, 972-977.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Euonymus japonicus
2,2'-dipyridyl
-
Euonymus japonicus
5,5-diphenylhydantoin
-
Euonymus japonicus
glycerol uncompetitive to DL-glyceraldehyde Euonymus japonicus
hydroxylamine
-
Euonymus japonicus
iodoacetamide slight Euonymus japonicus
Li2SO4 200 mM: inhibition Euonymus japonicus
N-ethylmaleimide
-
Euonymus japonicus
NADP+ competitve to NADPH Euonymus japonicus
p-hydroxymercuribenzoate
-
Euonymus japonicus
Phenobarbital
-
Euonymus japonicus
pyrazole slight Euonymus japonicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
4-nitrobenzaldehyde
-
Euonymus japonicus
0.004
-
4-Pyridinecarboxaldehyde
-
Euonymus japonicus
0.01 0.015 NADPH
-
Euonymus japonicus
0.034
-
hexanal
-
Euonymus japonicus
0.046
-
3-Pyridinecarboxaldehyde
-
Euonymus japonicus
0.087
-
n-Pentanal
-
Euonymus japonicus
0.099
-
2-pyridinecarboxaldehyde
-
Euonymus japonicus
0.295
-
benzaldehyde
-
Euonymus japonicus
0.444
-
Butyraldehyde
-
Euonymus japonicus
0.68
-
Phenylglyoxal
-
Euonymus japonicus
1.8
-
glycoaldehyde
-
Euonymus japonicus
3.4
-
DL-glyceraldehyde
-
Euonymus japonicus
10.6
-
2-deoxygalactose
-
Euonymus japonicus
17.5
-
2-Deoxyribose
-
Euonymus japonicus
18.9
-
Glyoxal
-
Euonymus japonicus
28.1
-
D-erythrose
-
Euonymus japonicus
227.1
-
D-galactose
-
Euonymus japonicus
287.2
-
L-arabinose
-
Euonymus japonicus

Metals/Ions

Metals/Ions Comment Organism Structure
Li2SO4 200 mM: inhibition Euonymus japonicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
2 * 36000, SDS-PAGE Euonymus japonicus
67000
-
gel filtration Euonymus japonicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NAD(P)H Euonymus japonicus wide specificity alditol + NAD(P)+
-
r
aldose + NAD(P)H Celastrus orbiculatus wide specificity alditol + NAD(P)+
-
r
aldose + NAD(P)H Euonymus sp. wide specificity alditol + NAD(P)+
-
r
D-galactose + NADPH Euonymus japonicus
-
?
-
r
D-galactose + NADPH Celastrus orbiculatus
-
?
-
r
D-galactose + NADPH Euonymus sp.
-
?
-
r

Organism

Organism UniProt Comment Textmining
Celastrus orbiculatus
-
-
-
Euonymus japonicus
-
-
-
Euonymus sp.
-
distribution in various species
-

Purification (Commentary)

Purification (Comment) Organism
-
Euonymus japonicus

Source Tissue

Source Tissue Comment Organism Textmining
fruit
-
Celastrus orbiculatus
-
fruit
-
Euonymus sp.
-
leaf
-
Euonymus japonicus
-
leaf
-
Celastrus orbiculatus
-
leaf
-
Euonymus sp.
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.24
-
-
Euonymus japonicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-D-deoxygalactose + NADPH
-
Euonymus japonicus ?
-
r
2-deoxyribose + NADPH
-
Euonymus japonicus ?
-
r
3-pyridinecarboxaldehyde + NADPH + H+
-
Euonymus japonicus 3-pyridinemethanol + NADP+
-
r
4-nitrobenzaldehyde + NAD(P)H
-
Euonymus japonicus 4-nitrobenzyl alcohol + NAD(P)+
-
?
4-pyridinecarboxaldehyde + NADPH + H+
-
Euonymus japonicus 4-pyridinemethanol + NADP+
-
r
acetaldehyde + NAD(P)H + H+
-
Euonymus japonicus ethanol + NAD(P)+
-
?
alditol + NAD(P)+
-
Euonymus japonicus aldose + NAD(P)H
-
r
alditol + NAD(P)+
-
Celastrus orbiculatus aldose + NAD(P)H
-
r
alditol + NAD(P)+
-
Euonymus sp. aldose + NAD(P)H
-
r
aldose + NAD(P)H wide specificity Euonymus japonicus alditol + NAD(P)+
-
r
aldose + NAD(P)H wide specificity Celastrus orbiculatus alditol + NAD(P)+
-
r
aldose + NAD(P)H wide specificity Euonymus sp. alditol + NAD(P)+
-
r
benzaldehyde + NAD(P)H
-
Euonymus japonicus benzyl alcohol + NAD(P)+
-
?
butyraldehyde + NAD(P)H
-
Euonymus japonicus butanol + NAD(P)+
-
?
D-erythrose + NAD(P)H
-
Euonymus japonicus erythritol + NAD(P)+
-
?
D-galactose + NAD(P)H
-
Euonymus japonicus dulcitol + NAD(P)+
-
r
D-galactose + NADPH
-
Euonymus japonicus ?
-
r
D-galactose + NADPH
-
Celastrus orbiculatus ?
-
r
D-galactose + NADPH
-
Euonymus sp. ?
-
r
DL-glyceraldehyde + NAD(P)H
-
Euonymus japonicus glycerol + NAD(P)+
-
r
glycoaldehyde + NADPH
-
Euonymus japonicus ethylene glycol + NADP+
-
?
glyoxal + NADPH
-
Euonymus japonicus ?
-
?
hexanal + NADPH + H+
-
Euonymus japonicus hexanol + NADP+
-
r
L-arabinose + NAD(P)H
-
Euonymus japonicus L-arabitol + NAD(P)+
-
r
methylglyoxal + NADPH i.e. pyruvaldehyde Euonymus japonicus ?
-
?
additional information requirement for a free aldehyde group Euonymus japonicus ?
-
?
additional information requirement for a free aldehyde group Celastrus orbiculatus ?
-
?
additional information requirement for a free aldehyde group Euonymus sp. ?
-
?
n-pentanal + NAD(P)H + H+
-
Euonymus japonicus n-pentanol + NAD(P)+
-
?
phenylglyoxal + NAD(P)H
-
Euonymus japonicus ?
-
?
propionaldehyde + NAD(P)H
-
Euonymus japonicus propanol + NAD(P)+
-
?
pyridinecarboxaldehyde + NAD(P)H 2-, 3- and 4-pyridinecarboxaldehyde Euonymus japonicus pyridylmethanol + NAD(P)+
-
?

Subunits

Subunits Comment Organism
dimer 2 * 36000, SDS-PAGE Euonymus japonicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
phosphate buffer, Tris-HCl buffer, substrate: DL-glyceraldehyde 3-pyridine carboxaldehyde Euonymus japonicus
8.6 9 glycine-NaOH buffer, substrate: DL-glyceraldehyde 3-pyridine carboxaldehyde Euonymus japonicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Euonymus japonicus
NADPH
-
Celastrus orbiculatus
NADPH
-
Euonymus sp.