Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-[(2R)-2-phenylpropyl]hex-4-enamide | 73.94% inhibition at 0.01 mM | Homo sapiens | |
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-[(2S)-2-phenylpropyl]hex-4-enamide | 59.15% inhibition at 0.01 mM | Homo sapiens | |
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-[2-(2-methylphenyl)ethyl]hex-4-enamide | 84% inhibition at 0.01 mM | Homo sapiens | |
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-[2-(4-methylphenyl)ethyl]hex-4-enamide | 73.42% inhibition at 0.01 mM | Homo sapiens | |
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-[2-(pyridin-2-yl)ethyl]hex-4-enamide | 59.38% inhibition at 0.01 mM | Homo sapiens | |
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-[2-(pyridin-4-yl)ethyl]hex-4-enamide | 57.38% inhibition at 0.01 mM | Homo sapiens | |
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-[3-(morpholin-4-yl)propyl]hex-4-enamide | 36.05% inhibition at 0.01 mM | Homo sapiens | |
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-N-(3-methoxyphenyl)-4-methylhex-4-enamide | 30.82% inhibition at 0.01 mM | Homo sapiens | |
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-N-(4-methoxyphenyl)-4-methylhex-4-enamide | 54.84% inhibition at 0.01 mM | Homo sapiens | |
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-N-[2-(4-methoxyphenyl)ethyl]-4-methylhex-4-enamide | 96.13% inhibition at 0.01 mM | Homo sapiens | |
(4E)-N-[(4-butylphenyl)methyl]-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide | 93.62% inhibition at 0.01 mM | Homo sapiens | |
(4E)-N-[2-(2-chlorophenyl)ethyl]-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide | 72.04% inhibition at 0.01 mM | Homo sapiens | |
(4E)-N-[2-(2H-1,3-benzodioxol-5-yl)ethyl]-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide | 87.09% inhibition at 0.01 mM | Homo sapiens | |
(4E)-N-[2-(4-chlorophenyl)ethyl]-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide | 81.36% inhibition at 0.01 mM | Homo sapiens | |
(4E)-N-[2-(furan-2-yl)ethyl]-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide | 67.18% inhibition at 0.01 mM | Homo sapiens | |
mizoribine | competitive inhibitor | Homo sapiens | |
mycophenolate mofetil | - |
Homo sapiens | |
Mycophenolic acid | reversible, potent, uncompetitive inhibitor, 99.9% inhibition at 0.01 mM | Homo sapiens | |
mycophenolic acid sodium | - |
Homo sapiens | |
ribavirin | competitive inhibitor | Homo sapiens | |
tiazofurin | competitive inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + NAD+ + H2O | Homo sapiens | - |
XMP + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P12268 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
DU-145 cell | - |
Homo sapiens | - |
glioblastoma cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
prostate gland cancer cell | - |
Homo sapiens | - |
U-87MG cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + NAD+ + H2O | - |
Homo sapiens | XMP + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IMPDH2 | - |
Homo sapiens |
inosine 5-monophosphate dehydrogenase 2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00033 | - |
isoform IMPDH2, at pH 8.6 and 37°C | Homo sapiens | (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-N-[2-(4-methoxyphenyl)ethyl]-4-methylhex-4-enamide | |
0.00048 | - |
isoform IMPDH2, at pH 8.6 and 37°C | Homo sapiens | (4E)-N-[(4-butylphenyl)methyl]-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide | |
0.0005 | - |
isoform IMPDH2, at pH 8.6 and 37°C | Homo sapiens | (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-[2-(2-methylphenyl)ethyl]hex-4-enamide | |
0.00051 | - |
isoform IMPDH2, at pH 8.6 and 37°C | Homo sapiens | (4E)-N-[2-(2H-1,3-benzodioxol-5-yl)ethyl]-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide | |
0.00057 | - |
isoform IMPDH2, at pH 8.6 and 37°C | Homo sapiens | (4E)-N-[2-(4-chlorophenyl)ethyl]-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide | |
0.0006 | - |
isoform IMPDH2, at pH 8.6 and 37°C | Homo sapiens | (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-[2-(4-methylphenyl)ethyl]hex-4-enamide | |
0.00073 | - |
isoform IMPDH2, at pH 8.6 and 37°C | Homo sapiens | (4E)-N-[2-(2-chlorophenyl)ethyl]-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide | |
0.00082 | - |
isoform IMPDH2, at pH 8.6 and 37°C | Homo sapiens | (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-[(2R)-2-phenylpropyl]hex-4-enamide |