Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(4-bromophenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]ethan-1-one | - |
Mycobacterium tuberculosis | |
1-[(4-methoxyphenyl)methyl]-5-[[(naphthalen-2-yl)oxy]methyl]-1H-1,2,3-triazole | 52.4% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
2-(4-benzoylphenyl)-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)propanamide | 95.2% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
2-(4-fluoronaphthalen-1-yl)-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide | 99.9% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
2-chloro-N,N-dimethyl-5-[([2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]carbamoyl)amino]benzamide | - |
Mycobacterium tuberculosis | |
2-[4-([1-[(2-fluorophenyl)methyl]-1H-1,2,3-triazol-5-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole | 71% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
2-[4-([1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-5-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole | 35% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
2-[4-([1-[([1,1'-biphenyl]-4-yl)methyl]-1H-1,2,3-triazol-5-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole | 72.6% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
4-[(5-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazol-1-yl)methyl]benzonitrile | 43.5% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
Mycophenolic acid | complete inhibition at 0.01 mM, 83% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
N2-(2,3-dichlorophenyl)-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]-L-alaninamide | - |
Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + NAD+ + H2O | Mycobacterium tuberculosis | - |
XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | Mycobacterium tuberculosis H37Rv | - |
XMP + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WKI7 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WKI7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + NAD+ + H2O | - |
Mycobacterium tuberculosis | XMP + NADH + H+ | - |
? | |
IMP + NAD+ + H2O | - |
Mycobacterium tuberculosis H37Rv | XMP + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
guaB2 | - |
Mycobacterium tuberculosis |
IMPDH2 | - |
Mycobacterium tuberculosis |
inosine 5'-monophosphate dehydrogenase | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000014 | - |
N2-(2,3-dichlorophenyl)-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]-L-alaninamide | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
0.000017 | - |
2-chloro-N,N-dimethyl-5-[([2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]carbamoyl)amino]benzamide | pH and temperature not specified in the publication | Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00304 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 2-(4-fluoronaphthalen-1-yl)-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide | |
0.0062 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 2-(4-benzoylphenyl)-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)propanamide | |
0.0272 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | Mycophenolic acid | |
0.1747 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 4-[(5-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazol-1-yl)methyl]benzonitrile |