Application | Comment | Organism |
---|---|---|
diagnostics | IMPDH activity is measured in adults without thiopurine treatment as well as in adult and paediatric patients treated with thiopurines. A wide interindividual variability in IMPDH activity in erythrocytes is observed. No difference in IMPDH activity is found between untreated subjects and adult and paediatric patients on thiopurine therapy. The method described is useful in the determination of IMPDH phenotype from patients on thiopurine therapy and in the investigation of the potential relationship between IMPDH activity in erythrocytes and the occurrence of adverse events and drug response variability | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + NAD+ + H2O | Homo sapiens | - |
XMP + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P12268 | IMPDH2 | - |
Homo sapiens | P20839 | IMPDH1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | from healthy adults and paediatric patients on thiopurine therapy | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + beta-NAD+ + H2O | - |
Homo sapiens | XMP + beta-NADH + H+ | - |
? | |
IMP + NAD+ + H2O | - |
Homo sapiens | XMP + NADH + H+ | - |
? | |
additional information | assay method optimization. XMP detection and quantification by anion exchange chromatography | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IMPDH1 | - |
Homo sapiens |
IMPDH2 | - |
Homo sapiens |
inosine 5-monophosphate dehydrogenase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
- |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
beta-NAD+ | - |
Homo sapiens |