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Literature summary for 1.1.1.205 extracted from

  • Zhou, J.; Zhang, X.; He, K.; Wang, W.; Ni, Y.; Zhu, H.; Yu, Z.; Mao, A.; Lv, L.
    Characterization and proteome analysis of inosine 5-monophosphate dehydrogenase in epidemic Streptococcus suis serotype 2 (2014), Curr. Microbiol., 68, 663-669.
    View publication on PubMed
Search for more literature for 1.1.1.205

Protein Variants

Protein Variants Comment Organism
additional information construction of an IMPDH knockout mutant strain ZY05719 Streptococcus suis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
IMP + NAD+ + H2O Streptococcus suis
-
 XMP + NADH + H+
-
 ?
IMP + NAD+ + H2O Streptococcus suis ZY05719
-
 XMP + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus suis A0A0K2E8F8 serotype 2, SS2, strain ZY05719 is isolated from diseased pigs in Sichuan Province, China, in 2005
-
Streptococcus suis ZY05719 A0A0K2E8F8 serotype 2, SS2, strain ZY05719 is isolated from diseased pigs in Sichuan Province, China, in 2005
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IMP + NAD+ + H2O
-
 Streptococcus suis XMP + NADH + H+
-
 ?
IMP + NAD+ + H2O
-
 Streptococcus suis ZY05719 XMP + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
IMPDH
-
 Streptococcus suis
inosine 5-monophosphate dehydrogenase
-
 Streptococcus suis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Streptococcus suis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Streptococcus suis

General Information

General Information Comment Organism
malfunction IMPDH enzyme deletion leads to suppression of the glycolytic pathway enzymes triosephosphate isomerase (TPI) and glyceraldehyde phosphate dehydrogenase (GAPDH). The adhesion to host cells is the crucial step to cause infection for the pathogen, and reduction of adhesion of the IMPDH deletion mutant strain to some extent causes the attenuated virulence of the IMPDH deletion mutant strain in pigs, reduced adhesion ofthe mutant strain to PK15 and HEp-2 cells Streptococcus suis