Literature summary for 1.1.1.205 extracted from

Maiguma, T.; Yosida, T.; Otsubo, K.; Okabe, Y.; Sugitani, A.; Tanaka, M.; Oishi, R.; Teshima, D.
Evaluation of inosin-5-monophosphate dehydrogenase activity during maintenance therapy with tacrolimus (2010), J. Clin. Pharm. Ther., 35, 79-85.

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Application

Application	Comment	Organism
medicine	study on a target range for inosine 5'-monophosphate dehydrogenase activity in maintenance therapy with tacrolimus, on patients with renal transplants and healthy volunteers. Inosine 5'-monophosphate dehydrogenase activity in cell lysates can be reliably determined indirectly by measuring xanthosine 5'-monophophate in cell lysates supplemented with IMP and beta-nicotine adenine dinucleotide using an HPLC method. Cell lysates show a 5-6 nmol /l IC50 mycophenolic acid concentration. Tacrolimus, cyclosporine and prednisolone do not affect IMPDH activity. The peak mycophenolic acid concentration is achieved at 1 h after dosing. IMPDH activity decreases to 75% and 67% at 1 and 2 h after dosing respectively	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	tacrolimus, cyclosporine and prednisolone do not affect IMPDH activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

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Release 2023.1 (January 2023)