Application | Comment | Organism |
---|---|---|
medicine | a poorer response to mycophenolic acid therapy in some individuals may be due to the presence of the rs11706052 polymorphism | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Mycophenolic acid | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lymphocyte | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
IMPDH2 | - |
Homo sapiens |
inosine 5'-monophosphate dehydrogenase 2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | presence of rs11706052 polymorphism reduces the antiproliferative effect of mycophenolic acid on lymphocytes by approximately 50% compared with the IMPDH2 wild-type form at therapeutic relevant concentrations of 10 microM/l and 25 microM/l | Homo sapiens |