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Literature summary for 1.1.1.205 extracted from

  • Winnicki, W.; Weigel, G.; Sunder-Plassmann, G.; Bajari, T.; Winter, B.; Herkner, H.; Sengoelge, G.
    An inosine 5-monophosphate dehydrogenase 2 single-nucleotide polymorphism impairs the effect of mycophenolic acid (2010), Pharmacogenomics J., 10, 70-76.
    View publication on PubMed

Application

Application Comment Organism
medicine a poorer response to mycophenolic acid therapy in some individuals may be due to the presence of the rs11706052 polymorphism Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Mycophenolic acid
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
IMPDH2
-
Homo sapiens
inosine 5'-monophosphate dehydrogenase 2
-
Homo sapiens

General Information

General Information Comment Organism
physiological function presence of rs11706052 polymorphism reduces the antiproliferative effect of mycophenolic acid on lymphocytes by approximately 50% compared with the IMPDH2 wild-type form at therapeutic relevant concentrations of 10 microM/l and 25 microM/l Homo sapiens