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Literature summary for 1.1.1.205 extracted from

  • Wang, J.; Zeevi, A.; Webber, S.; Girnita, D.M.; Addonizio, L.; Selby, R.; Hutchinson, I.V.; Burckart, G.J.
    A novel variant L263F in human inosine 5-monophosphate dehydrogenase 2 is associated with diminished enzyme activity (2007), Pharmacogenet. Genomics, 17, 283-290.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
L263F site-directed mutagenesis, about 10% of wild-type activity Homo sapiens
additional information identification of nine genetic variants in type II enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Mycophenolic acid
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0163
-
NAD+ wild-type, 37°C, pH 8.0 Homo sapiens
0.0227
-
NAD+ mutant L263F, 37°C, pH 8.0 Homo sapiens
0.042
-
inosine 5'-phosphate mutant L263F, 37°C, pH 8.0 Homo sapiens
0.0458
-
inosine 5'-phosphate wild-type, 37°C, pH 8.0 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
IMPDH type II
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O
-
Homo sapiens xanthosine 5'-phosphate + NADH
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.17
-
inosine 5'-phosphate mutant L263F, 37°C, pH 8.0 Homo sapiens
1.47
-
inosine 5'-phosphate wild-type, 37°C, pH 8.0 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.011
-
Mycophenolic acid wild-type, 37°C, pH 8.0 Homo sapiens
0.0182
-
Mycophenolic acid mutant L263F, 37°C, pH 8.0 Homo sapiens