Literature summary for 1.1.1.205 extracted from

Mizushina, Y.; Dairaku, I.; Yanaka, N.; Takeuchi, T.; Ishimaru, C.; Sugawara, F.; Yoshida, H.; Kato, N.
Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase (2007), Biochimie, 89, 581-590.

Search for more literature for 1.1.1.205

Crystallization (Commentary)

Crystallization (Comment)	Organism
modeling of enzyme in complex with eicosadienoic acid. Eicosadienoic acid binds to residue C331 in the active site	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
eicosadienoic acid	competitive to inosine 5'-phosphate	Mus musculus
linoleic acid	-	Mus musculus
additional information	not inhibitory: linoelaidic acid, methyl linoleate, cis-9-octadecen-1-ol	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	IMPDH type II	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
inosine 5'-phosphate + NAD+ + H2O	-	Mus musculus	xanthosine 5'-phosphate + NADH	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0031	-	eicosadienoic acid	pH 8.0, 37°C	Mus musculus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0161	-	pH 8.0, 37°C	Mus musculus	eicosadienoic acid

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Release 2023.1 (January 2023)