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Literature summary for 1.1.1.205 extracted from
- Species-specific inhibition of inosine 5'-monophosphate dehydrogenase by mycophenolic acid (1999), Biochemistry, 38, 15388-15397.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E431Q | 6fold decrease of Ki for mycophenolic acid | Tritrichomonas suis |
| K310R | 10fold decrease of Ki for mycophenolic acid, increase of Km for IMP and NAD+ | Tritrichomonas suis |
| K310R/E431Q | 20fold increase in sensitivity to mycophenolic acid | Tritrichomonas suis |
| Q441E | less than 0.045% of wild type activity, therefore no further characterization possible | Homo sapiens |
| R322K | less than 0.045% of wild type activity, therefore no further characterization possible | Homo sapiens |
| R322K/Q441E | less than 0.045% of wild type activity, therefore no further characterization possible | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Mycophenolic acid | - |
Homo sapiens |  |
| Mycophenolic acid | - |
Tritrichomonas suis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Tritrichomonas suis | - |
wild type and mutants | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Tritrichomonas suis |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | wild type and mutants | Homo sapiens | |
| additional information | - |
additional information | wild type and mutants | Tritrichomonas suis |
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Release 2023.1 (January 2023)
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