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Literature summary for 1.1.1.205 extracted from

  • Jackson, R.C.; Morris, H.P.; Weber, G.
    Partial purification, properties and regulation of inosine 5-phosphate dehydrogenase in normal and malignant rat tissues (1977), Biochem. J., 166, 1-10.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2-mercaptoethanol inhibits above 2 mM Rattus norvegicus
6-thio-IMP
-
Rattus norvegicus
AMP
-
Rattus norvegicus
dithioerythrol inhibits above 1 mM Rattus norvegicus
GMP competitive with respect to IMP Rattus norvegicus
Mycophenolic acid
-
Rattus norvegicus
NAD+
-
Rattus norvegicus
NADH
-
Rattus norvegicus
NADPH 50% inhibition at 0.14 mM Rattus norvegicus
xanthosine 5'-phosphate
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
hepatoma cells 3924 A Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
IMP + NAD+ + H2O = XMP + NADH + H+ ordered sequential mechanism Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-
Morris hepatoma 3924A cell
-
Rattus norvegicus
-
spleen highest activity of rat tissues tested Rattus norvegicus
-
thymus highest activity of rat tissues tested Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
activity in various organs Rattus norvegicus
0.00649
-
-
Rattus norvegicus

Storage Stability

Storage Stability Organism
-20°C Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O
-
Rattus norvegicus xanthosine 5'-phosphate + NADH
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.1
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
7 9 pH 7: about 45% of activity maximum, pH 9: about 85% of activity maximum Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information
-
Rattus norvegicus