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Literature summary for 1.1.1.205 extracted from
- IMP dehydrogenase. II. Purification and properties of the enzyme from Yoshida sarcoma ascites tumor cells (1983), J. Biochem., 94, 1605-1613.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 6-Chloro-9-beta-D-ribofuranosylpurine 5 '-phosphate | - |
Rattus norvegicus |  |
| AMP | - |
Rattus norvegicus | |
| GMP | - |
Rattus norvegicus | |
| NAD+ | - |
Rattus norvegicus | |
| p-chloromercuribenzoate | inhibition can be restored by addition of DTT | Rattus norvegicus | |
| xanthosine 5'-phosphate | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Rattus norvegicus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | full activity in presence of K+ | Rattus norvegicus | |
| Na+ | can partially replace K+ in activation | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
enzyme tends to aggregate owing to its own physicochemical characteristics | Rattus norvegicus |
| 68000 | - |
2 * 68000, Yoshida sarcoma ascites tumor cells, SDS-PAGE | Rattus norvegicus |
| 127000 | - |
Yoshida sarcoma ascites tumor cells, gel filtration in presence of 10% (NH4)2SO4 | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Yoshida sarcoma ascites cells | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| homogeneitiy | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Yoshida ascites sarcoma cell | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.19 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| inosine 5'-phosphate + NAD+ + H2O | - |
Rattus norvegicus | xanthosine 5'-phosphate + NADH | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 68000, Yoshida sarcoma ascites tumor cells, SDS-PAGE | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | 8 | - |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.7 | 9 | pH 6.7: about 40% of activity maximum, pH 9.0: about 55% of activity maximum | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Rattus norvegicus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.109 | - |
xanthosine 5'-phosphate | - |
Rattus norvegicus | |
| 0.13 | - |
GMP | - |
Rattus norvegicus | |
| 0.854 | - |
AMP | - |
Rattus norvegicus | |
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