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Literature summary for 1.1.1.205 extracted from

  • Buzzee, D.H.; Levin, A.P.
    Demonstration of an effector site for the enzyme inosine 5-phosphate dehydrogenase (1968), Biochem. Biophys. Res. Commun., 30, 673-677.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
GMP feedback inhibitor; feed-back inhibitor eliciting 'allosteric' kinetics of the enzyme, determination of the GMP binding site Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics Salmonella enterica subsp. enterica serovar Typhimurium
additional information
-
additional information Km over the range of pH 7.3-8.5 Salmonella enterica subsp. enterica serovar Typhimurium
0.02
-
inosine 5'-phosphate pH 7.5, 22°C Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O Salmonella enterica subsp. enterica serovar Typhimurium the reaction is irreversible over the range of pH 5.5 to pH 8.8, step in guanylic acid biosynthesis xanthosine 5'-phosphate + NADH
-
ir

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial purification Salmonella enterica subsp. enterica serovar Typhimurium
partially by ammonium sulfate fractionation Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium xanthosine 5'-phosphate + NADH
-
ir
inosine 5'-phosphate + NAD+ + H2O the reaction is irreversible over the range of pH 5.5 to pH 8.8, step in guanylic acid biosynthesis Salmonella enterica subsp. enterica serovar Typhimurium xanthosine 5'-phosphate + NADH
-
ir
inosine 5'-phosphate + NAD+ + H2O the reaction is irreversible over the range of pH 5.5 to pH 8.8 Salmonella enterica subsp. enterica serovar Typhimurium xanthosine 5'-phosphate + NADH
-
ir

Synonyms

Synonyms Comment Organism
IMP-DH
-
Salmonella enterica subsp. enterica serovar Typhimurium
IMP:NAD oxidoreductase
-
Salmonella enterica subsp. enterica serovar Typhimurium
inosine 5'-phosphate dehydrogenase
-
Salmonella enterica subsp. enterica serovar Typhimurium

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at room temperature Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Salmonella enterica subsp. enterica serovar Typhimurium

pH Range

pH Minimum pH Maximum Comment Organism
5.5 8.8
-
Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Salmonella enterica subsp. enterica serovar Typhimurium

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information Ki over the range of pH 7.3 to 8.5 Salmonella enterica subsp. enterica serovar Typhimurium