Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AL-1576 | 0.5 microM, (10 x KI), 13fold higher affinity for aldehyde reductase than for aldose reductase; 0.5 microM, (10 x KI), 13fold higher affinity for aldehyde reductase than for aldose reductase, reversible | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
apical plasma membrane | proximal tubules, high concentration | Mus musculus | 16324 | - |
cytosol | low concentration | Mus musculus | 5829 | - |
membrane | proximal tubules | Mus musculus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glucuronate + NADPH | Mus musculus | - |
? | - |
? | |
glucuronate + NADPH | Mus musculus C57BL/6 | - |
? | - |
? | |
glucuronate + NADPH + H+ | Mus musculus | - |
? | - |
? | |
glucuronate + NADPH + H+ | Mus musculus C57BL/6 | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9JII6 | - |
- |
Mus musculus | Q9JII6 | C57BL/6 | - |
Mus musculus C57BL/6 | Q9JII6 | C57BL/6 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Mus musculus | - |
kidney | fetal kidney, 10fold higher enzymatic activity observed compared with other tissues | Mus musculus | - |
kidney cortex | represents as much as 1% of total cytosolic protein in the kidney | Mus musculus | - |
liver | - |
Mus musculus | - |
stomach | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
10fold higher enzymatic activity observed in kidney compared with other tissues, enzyme activity depends on the human´s age | Mus musculus |
additional information | - |
10fold higher enzymatic activity observed in kindney compare with other tissues, enzyme activity depends on the animals age, activity approaches a plateau by day 35 and does not differ between male and female mice | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucuronate + NADPH | 0.1 M phosphat buffer, pH 7.0 | Mus musculus | ? | - |
? | |
D-glucuronate + NADPH | 0.1 M phosphat buffer, pH 7.0 | Mus musculus C57BL/6 | ? | - |
? | |
D-glucuronate + NADPH + H+ | 0.1 M phosphate buffer, pH 7.0 | Mus musculus | ? | - |
? | |
D-glucuronate + NADPH + H+ | 0.1 M phosphate buffer, pH 7.0 | Mus musculus C57BL/6 | ? | - |
? | |
glucuronate + NADPH | - |
Mus musculus | ? | - |
? | |
glucuronate + NADPH | - |
Mus musculus C57BL/6 | ? | - |
? | |
glucuronate + NADPH + H+ | - |
Mus musculus | ? | - |
? | |
glucuronate + NADPH + H+ | - |
Mus musculus C57BL/6 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AKR1A1 | - |
Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay pH | Mus musculus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay pH | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Mus musculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
AL-1576 | - |
Mus musculus |