Any feedback?
Literature summary for 1.1.1.197 extracted from
- Polycyclic aromatic hydrocarbon quinones and glutathione thioethers as substrates and inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase (1987), J. Biol. Chem., 262, 12448-12451.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-glutathionyl-2-hydroxy-3(allyloxy)propane | competitive inhibition of prostaglandin B1 oxidation | Homo sapiens |  |
| glutathione-9-hydroxy-prostaglandin A1 thioether | inhibition of polycyclic aromatic hydrocarbon quinone reduction | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00018 | - |
4,5-benzo[a]pyrenequinone | - |
Homo sapiens | |
| 0.00033 | - |
glutathione-prostaglandin A1 thioether | - |
Homo sapiens | |
| 0.00036 | - |
9,10-phenanthrenequinone | - |
Homo sapiens | |
| 0.00051 | - |
5,6-chrysenequinone | - |
Homo sapiens | |
| 0.00087 | - |
7,8-benzo[a]pyrenequinone | - |
Homo sapiens | |
| 0.0024 | - |
2-methyl-3-glutathionyl-1,4-benzoquinone | - |
Homo sapiens | |
| 0.0034 | - |
2-methyl-3-glutathionyl-1,4-naphthoquinone | - |
Homo sapiens | |
| 0.0076 | - |
menadione | - |
Homo sapiens | |
| 0.03 | - |
toluquinone | - |
Homo sapiens | |
| 0.09 | - |
prostaglandin A1 | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| placenta | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.09 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-methyl-3-glutathionyl-1,4-benzoquinone + NADPH | toluquinone thioether | Homo sapiens | ? + NADP+ | - |
? | |
| 2-methyl-3-glutathionyl-1,4-naphthoquinone + NADPH | menadione thioether | Homo sapiens | ? + NADP+ | - |
? | |
| 4,5-benzo[a]pyrenequinone + NADPH | - |
Homo sapiens | ? + NADP+ | - |
? | |
| 5,6-chrysenequinone + NADPH | - |
Homo sapiens | ? + NADP+ | - |
? | |
| 7,8-benzo[a]pyrenequinone + NADPH | - |
Homo sapiens | ? + NADP+ | - |
? | |
| 9,10-phenanthrenequinone + NADPH | - |
Homo sapiens | ? + NADP+ | - |
? | |
| glutathione-9-hydroxy-prostaglandin A1 thioether + NADP+ | - |
Homo sapiens | ? + NADPH | - |
? | |
| glutathione-prostaglandin A1 thioether + NADP+ | PGA1-SG, excellent substrate for the placental enzyme | Homo sapiens | ? + NADPH | - |
? | |
| menadione + NADPH | - |
Homo sapiens | ? + NADP+ | - |
? | |
| additional information | the trans-dihydrodiols trans-dihydroxy-4,5-dihydrobenzo[alpha]pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo[alpha]pyrene, trans-3,4-dihydroxy-3,4-dihydrobenz[alpha]anthracene and its 7-methyl, 12-methyl, and 7,12-dimethyl derivatives are not substrates for the enzyme | Homo sapiens | ? | - |
? | |
| prostaglandin A1 + NADP+ | - |
Homo sapiens | 15-oxoprostaglandin A1 + NADPH + H+ | - |
? | |
| prostaglandin B1 + NADP+ | - |
Homo sapiens | 15-oxoprostaglandin B1 + NADPH + H+ | - |
? | |
| toluquinone + NADPH | - |
Homo sapiens | ? + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 9-ketoprostaglandin reductase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
