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Literature summary for 1.1.1.19 extracted from

  • Kaufman, E.E.; Nelson, T.
    An overview of gamma-hydroxybutyrate catabolism: the role of the cytosolic NADP+-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway (1991), Neurochem. Res., 16, 965-974.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-mercaptoethanol
-
Mesocricetus auratus
2-mercaptoethanol preincubation of gamma-hydroxybutyrate reductase revealed no inhibitory effect Rattus norvegicus
acetoacetate
-
Mesocricetus auratus
acetoacetate
-
Rattus norvegicus
alpha-ketoglutarate
-
Mesocricetus auratus
alpha-ketoglutarate
-
Rattus norvegicus
branched alpha-ketoacids
-
Mesocricetus auratus
branched alpha-ketoacids
-
Rattus norvegicus
dithiothreitol
-
Mesocricetus auratus
dithiothreitol preincubation of gamma-hydroxybutyrate reductase revealed no inhibitory effect Rattus norvegicus
DL-beta-hydroxybutyrate
-
Mesocricetus auratus
DL-beta-hydroxybutyrate
-
Rattus norvegicus
phenylacetate
-
Mesocricetus auratus
phenylacetate
-
Rattus norvegicus
Salicylates
-
Mesocricetus auratus
Salicylates
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00045
-
gamma-hydroxybutyrate coupled reaction of gamma-hydroxybutyrate oxidation and D-glucuronate reduction, brain and kidney Rattus norvegicus
0.00045
-
gamma-hydroxybutyrate enzyme from brain, D-glucuronate reduction-coupled assay Rattus norvegicus
0.0022
-
gamma-hydroxybutyrate kidney Rattus norvegicus
0.0022
-
gamma-hydroxybutyrate enzyme from kidney, uncoupled assay Rattus norvegicus
0.0025
-
gamma-hydroxybutyrate brain Rattus norvegicus
0.0025
-
gamma-hydroxybutyrate enzyme from brain, uncoupled assay Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucuronate + NADPH Homo sapiens
-
L-gulonate + NADP+
-
r
D-glucuronate + NADPH Rattus norvegicus
-
L-gulonate + NADP+
-
r
gamma-hydroxybutyrate + NADP+ Mesocricetus auratus preverably in a coupled reaction in vivo with reduction of D-glucuronate succinic semialdehyde + NADPH
-
?
L-gulonate + NADP+ Homo sapiens
-
D-glucuronate + NADPH
-
r
L-gulonate + NADP+ Rattus norvegicus
-
D-glucuronate + NADPH
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mesocricetus auratus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mesocricetus auratus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
kidney
-
Homo sapiens
-
kidney
-
Rattus norvegicus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
liver
-
Mesocricetus auratus
-
muscle
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucuronate + NADPH
-
Homo sapiens L-gulonate + NADP+
-
r
D-glucuronate + NADPH
-
Rattus norvegicus L-gulonate + NADP+
-
r
gamma-hydroxybutyrate + NADP+
-
Mesocricetus auratus succinic semialdehyde + NADPH
-
?
gamma-hydroxybutyrate + NADP+ preverably in a coupled reaction in vivo with reduction of D-glucuronate Mesocricetus auratus succinic semialdehyde + NADPH
-
?
gamma-hydroxybutyrate + NADP+
-
Rattus norvegicus succinic semialdehyde + NADPH + H+
-
r
L-gulonate + NADP+
-
Homo sapiens D-glucuronate + NADPH
-
r
L-gulonate + NADP+
-
Rattus norvegicus D-glucuronate + NADPH
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
shifted pH-optimum for the coupled reaction of oxidation of gamma-hydroxybutyrate and reduction of D-glucuronate in vitro Mesocricetus auratus
7.5
-
-
Rattus norvegicus
7.5
-
in vivo for coupled reaction of gamma-hydroxybutyrate oxidation and D-glucuronate reduction Mesocricetus auratus
9
-
substrate gamma-hydroxybutyrate, at pH 7.0 activity is reduced by 50% Mesocricetus auratus

pH Range

pH Minimum pH Maximum Comment Organism
7 10
-
Homo sapiens
7 10
-
Rattus norvegicus
7 10
-
Mesocricetus auratus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADP+
-
Rattus norvegicus
NADP+
-
Mesocricetus auratus
NADPH
-
Homo sapiens
NADPH
-
Rattus norvegicus
NADPH
-
Mesocricetus auratus