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Literature summary for 1.1.1.188 extracted from

  • Bresson, E.; Lacroix-Pepin, N.; Boucher-Kovalik, S.; Chapdelaine, P.; Fortier, M.A.
    The prostaglandin F synthase activity of the human aldose reductase AKR1B1 brings new lenses to look at pathologic conditions (2012), Front. Pharmacol., 3, 98.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibitors such as alrestatin, ponalrestat, and EBPC exhibit distinct and characteristic inhibition of prostaglandin F2alpha production in different cell models Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P15121
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
Homo sapiens
-
endothelium
-
Homo sapiens
-
prostate
-
Homo sapiens
-
uterine endometrium
-
Homo sapiens
-
vascular smooth muscle cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
AKR1B1
-
Homo sapiens
ALDR1
-
Homo sapiens
ALR2
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens interleukin IL-1beta is able to upregulate COX-2 and AKR1B1 proteins as well as prostaglandin F2alpha production under normal glucose concentrations. The promoter activity of AKR1B1 gene is increased by IL-1beta particularly around the multiple stress response region up