Crystallization (Comment) | Organism |
---|---|
homology modeling of enzyme in complex with inhibitor indomethacin | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(4-aminobenzyl)-5-methoxy-2-methylindoleacetic acid | - |
Homo sapiens | |
flurbiprofen | - |
Homo sapiens | |
Ibuprofen | - |
Homo sapiens | |
indomethacin | specific inhibition of isoform AKR1C3 versus AKR1C1 and AKR1C3 | Homo sapiens | |
indomethacin methyl ester | specific inhibition of isoform AKR1C3 versus AKR1C1 and AKR1C3 | Homo sapiens | |
Meclofenamic acid | - |
Homo sapiens | |
N-(4-chlorobenzoyl)-melatonin | specific inhibition of isoform AKR1C3 versus AKR1C1 and AKR1C3, not inhibitory to cyclooxygenases. Uncompetitive versus 9,10-phenynthrenequinone, competitive versus DELTA4-andostene-3,17-dione | Homo sapiens | |
naproxen | - |
Homo sapiens | |
sulindac | - |
Homo sapiens | |
Zomepirac | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0015 | - |
9,10-phenanthrenequinone | pH 7.0, 37°C | Homo sapiens | |
0.0066 | - |
androst-4-ene-3,17-dione | pH 7.0, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P42330 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
9,10-phenanthrenequinone + NADPH | - |
Homo sapiens | ? + NADP+ | - |
? | |
androst-4-ene-3,17-dione + NADPH | - |
Homo sapiens | ? + NADP+ | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0027 | - |
androst-4-ene-3,17-dione | pH 7.0, 37°C | Homo sapiens | |
1.4 | - |
9,10-phenanthrenequinone | pH 7.0, 37°C | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0007 | - |
pH 7.0, 37°C | Homo sapiens | Meclofenamic acid | |
0.0014 | - |
pH 7.0, 37°C | Homo sapiens | naproxen | |
0.0023 | - |
pH 7.0, 37°C | Homo sapiens | indomethacin | |
0.0023 | - |
pH 7.0, 37°C | Homo sapiens | indomethacin methyl ester | |
0.0034 | - |
pH 7.0, 37°C | Homo sapiens | sulindac | |
0.0078 | - |
pH 7.0, 37°C | Homo sapiens | flurbiprofen | |
0.0078 | - |
pH 7.0, 37°C | Homo sapiens | N-(4-chlorobenzoyl)-melatonin | |
0.0099 | - |
pH 7.0, 37°C | Homo sapiens | Ibuprofen | |
0.04 | - |
pH 7.0, 37°C | Homo sapiens | Zomepirac | |
0.052 | - |
pH 7.0, 37°C | Homo sapiens | 1-(4-aminobenzyl)-5-methoxy-2-methylindoleacetic acid |