Literature summary for 1.1.1.188 extracted from

Xiao, C.W.; Murphy, B.D.; Sirois, J.; Goff, A.K.
Down-regulation of oxytocin-induced cyclooxygenase-2 and prostaglandin F synthase expression by interferon-.tau. in bovine endometrial cells (1999), Biol. Reprod., 60, 656-663.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Oxytocin	increases prostaglandin F synthase mRNA synthesis	Bos taurus
phorbol 12-myristate 13-acetate	stimulates prostaglandin synthesis	Bos taurus

Inhibitors

Inhibitors	Comment	Organism	Structure
interferon tau	recombinant bovine interferon tau down-regulates mRNA gene expression of the prostaglandin F synthase after stimulation with oxytocin	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
uterine endometrium	epithelial	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
prostaglandin H2 + NADPH + H+	-	Bos taurus	(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Bos taurus

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Release 2023.1 (January 2023)