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Literature summary for 1.1.1.17 extracted from

  • Ladero, V.; Ramos, A.; Wiersma, A.; Goffin, P.; Schanck, A.; Kleerebezem, M.; Hugenholtz, J.; Smid, E.J.; Hols, P.
    High-level production of the low-calorie sugar sorbitol by Lactobacillus plantarum through metabolic engineering (2007), Appl. Environ. Microbiol., 73, 1864-1872.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information the enzyme competes with two sorbitol-6-phosphate dehydrogenase for D-fructose 6-phosphate, a mutant strain deficient for both L- and D-lactate dehydrogenase activities shows two highly active sorbitol-6-phosphate dehydrogenase genes srlD1 and srlD2, that are constitutively expressed at a high level in this mutant, the mannitol production of the mutant strain is reduced compared to the wild-type, overview Lactiplantibacillus plantarum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-mannitol 1-phosphate + NAD+ Lactiplantibacillus plantarum the enzyme competes with two sorbitol-6-phosphate dehydrogenase for D-fructose 6-phosphate, metabolic flux in engineered organisms, overview D-fructose 6-phosphate + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Lactiplantibacillus plantarum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-mannitol 1-phosphate + NAD+
-
Lactiplantibacillus plantarum D-fructose 6-phosphate + NADH + H+
-
r
D-mannitol 1-phosphate + NAD+ the enzyme competes with two sorbitol-6-phosphate dehydrogenase for D-fructose 6-phosphate, metabolic flux in engineered organisms, overview Lactiplantibacillus plantarum D-fructose 6-phosphate + NADH + H+
-
r

Synonyms

Synonyms Comment Organism
mannitol-1-phosphate dehydrogenase
-
Lactiplantibacillus plantarum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
in vivo Lactiplantibacillus plantarum

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Lactiplantibacillus plantarum
NADH
-
Lactiplantibacillus plantarum