Literature summary for 1.1.1.169 extracted from

Ciulli, A.; Williams, G.; Smith, A.G.; Blundell, T.L.; Abell, C.
Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods (2006), J. Med. Chem., 49, 4992-5000.

Search for more literature for 1.1.1.169

Inhibitors

Inhibitors	Comment	Organism	Structure
2'-phospho-ADP-ribose	competitive	Escherichia coli
2'-phospho-AMP	competitive	Escherichia coli
ADP	competitive	Escherichia coli
AMP	competitive	Escherichia coli
ATP	noncompetitive	Escherichia coli
additional information	protein-ligand interaction determination and analysis	Escherichia coli
phosphate	competitive	Escherichia coli

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	additional information	kinetics and thermodynamics, overview	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ketopantoate + NADPH	Escherichia coli	the enzyme is involved in pantothenate, i.e. vitamin B5, biosynthesis, which is a precursor for CoA	pantoate + NADP+	-	r

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	gene panE	-

Reaction

Reaction	Comment	Organism	Reaction ID
(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+	protein-ligand interactions, overview	Escherichia coli	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ketopantoate + NADPH	-	Escherichia coli	pantoate + NADP+	-	r
ketopantoate + NADPH	the enzyme is involved in pantothenate, i.e. vitamin B5, biosynthesis, which is a precursor for CoA	Escherichia coli	pantoate + NADP+	-	r

Synonyms

Synonyms	Comment	Organism
ketopantoate reductase	-	Escherichia coli
KPR	-	Escherichia coli

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.6	-	assay at	Escherichia coli

Cofactor

Cofactor	Comment	Organism	Structure
additional information	NAD+/NADH are poor cofactors	Escherichia coli
NADP+	protein-ligand interaction determination and analysis	Escherichia coli
NADPH	protein-ligand interaction determination and analysis	Escherichia coli

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.2	-	2'-phospho-ADP-ribose	pH 7.6	Escherichia coli
0.24	-	2'-phospho-AMP	pH 7.6	Escherichia coli
0.61	-	ATP	pH 7.6	Escherichia coli
1.05	-	ADP	pH 7.6	Escherichia coli
6.3	-	AMP	pH 7.6	Escherichia coli
27	-	phosphate	pH 7.6	Escherichia coli

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Release 2023.1 (January 2023)