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Literature summary for 1.1.1.159 extracted from

  • Haslewood, E.S.; Haslewood, G.A.D.
    The specificity of a 7alpha-hydroxy steroid dehydrogenase from Escherichia coli (1976), Biochem. J., 157, 207-210.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
12-ketochenodeoxycholic acid + NAD+
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Escherichia coli 7,12-diketochenodeoxycholic acid + NADH
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?
chenodeoxycholic acid + NAD(P)+ i.e. 3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid Escherichia coli 3alpha-hydroxy-7-oxo-5beta-cholan-24-oic acid + NAD(P)H
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cholic acid + NAD(P)+
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Escherichia coli 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
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glycochenodeoxycholic acid + NAD(P)+ i.e. N-[3alpha,7alpha-dihydroxy-24-oxocholan-24-yl]glycine, no reaction Escherichia coli N-[3alpha-hydroxy-7,24-dioxocholan-24-yl]glycine + NAD(P)H
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?
glycocholic acid + NAD+ i.e. N-[3alpha,7alpha,12alpha-trihydroxy-24-oxocholan-24-yl]glycine Escherichia coli N-[3alpha,12alpha-dihydroxy-7,24-dioxo-5beta-cholan-24-yl]glycine + NADH
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additional information wide variety of 5alpha- or 5beta-cholanoic acids, overview Escherichia coli ?
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taurocholic acid + NAD+ i.e. 2[[3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholan-24-yl]amino]ethane sulfonic acid Escherichia coli 2[[3alpha,12alpha-dihydroxy-7,24-dioxo-5beta-cholan-24-yl]amino]ethane sulfonic acid + NADH
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