Literature summary for 1.1.1.153 extracted from

Curtius, H.C.; Heintel, D.; Ghisla, S.; Kuster, T.; Leimbacher, W.; Niederwieser, A.
Tetrahydrobiopterin biosynthesis. Studies with specifically labeled (2H)NAD(P)H and 2H2O and of the enzymes involved (1985), Eur. J. Biochem., 148, 413-419.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
6-(S)-lactoyl-7,8-dihydropterin + NADPH	Homo sapiens	terminal step in the biosynthetic pathway for tetrahydrobiopterin	6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
liver, partially	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6-(S)-lactoyl-7,8-dihydropterin + NADPH	-	Homo sapiens	6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+	-	?
6-(S)-lactoyl-7,8-dihydropterin + NADPH	terminal step in the biosynthetic pathway for tetrahydrobiopterin	Homo sapiens	6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)