Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-Carboxypterin | IC50 0.03 mM | Rattus norvegicus | |
alpha-ketoglutarate | slight, IC50 5 mM | Rattus norvegicus | |
Cd2+ | IC50 0.1 mM | Rattus norvegicus | |
dicoumarol | IC50 0.0006 mM | Rattus norvegicus | |
Ethacrynic acid | IC50 0.03 mM | Rattus norvegicus | |
Hg2+ | IC50 0.00009 mM | Rattus norvegicus | |
indomethacin | IC50 0.06 mM | Rattus norvegicus | |
N-acetylserotonin | IC50 0.0006 mM | Rattus norvegicus | |
Phenobarbital | slight, IC50 0.6 mM | Rattus norvegicus | |
propionic acid | IC50 0.3 mM, pH 6.4 | Rattus norvegicus | |
pyrazole | slight, IC50 1 mM | Rattus norvegicus | |
rutin | IC50 0.06 mM | Rattus norvegicus | |
Zn2+ | IC50 0.4 mM | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00082 | - |
9,10-phenanthrene quinone | - |
Rattus norvegicus | |
0.0183 | - |
benzil | - |
Rattus norvegicus | |
0.043 | - |
benzylacetone | - |
Rattus norvegicus | |
0.118 | - |
1-phenyl-1,2-propanedione | cofactor NADH | Rattus norvegicus | |
0.14 | - |
propiophenone | - |
Rattus norvegicus | |
0.18 | - |
menadione | - |
Rattus norvegicus | |
0.43 | - |
p-nitrobenzaldehyde | - |
Rattus norvegicus | |
0.59 | - |
Phenylglyoxal | - |
Rattus norvegicus | |
0.75 | - |
p-quinone | - |
Rattus norvegicus | |
1.02 | - |
diacetyl | cosubstrate NADH | Rattus norvegicus | |
1.1 | - |
acetophenone | - |
Rattus norvegicus | |
4.4 | - |
methylglyoxal | - |
Rattus norvegicus | |
5.19 | - |
2,4-Pentanedione | - |
Rattus norvegicus | |
29 | - |
acetoin | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-(S)-lactoyl-7,8-dihydropterin + NADPH | Rattus norvegicus | - |
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
L-erythro-7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+ | enzyme also reduces carbonyl compounds of non-pteridine derivatives | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phenyl-1,2-propanedione + NADPH | - |
Rattus norvegicus | ? | - |
? | |
2,4-pentanedione + NADPH | - |
Rattus norvegicus | ? | - |
? | |
6-(S)-lactoyl-7,8-dihydropterin + NADPH | - |
Rattus norvegicus | 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+ | - |
? | |
9,10-phenanthrenequinone + NADP+ | - |
Rattus norvegicus | ? | - |
? | |
acetoin + NADPH | - |
Rattus norvegicus | ? | - |
? | |
acetophenone + NADPH | - |
Rattus norvegicus | ? | - |
? | |
benzil + NADPH | - |
Rattus norvegicus | ? | - |
? | |
benzylacetone + NADPH | - |
Rattus norvegicus | ? | - |
? | |
diacetyl + NADPH | - |
Rattus norvegicus | ? | - |
? | |
menadione + NADPH | - |
Rattus norvegicus | ? | - |
? | |
methylglyoxal + NADPH | - |
Rattus norvegicus | ? | - |
? | |
additional information | enzyme is quite similar to general aldo-keto reductases, especially to carbonyl reductase | Rattus norvegicus | ? | - |
? | |
p-nitrobenzaldehyde + NADPH | - |
Rattus norvegicus | p-nitrobenzyl alcohol + NADP+ | - |
? | |
p-quinone + NADPH | - |
Rattus norvegicus | ? | - |
? | |
phenylglyoxal + NADPH | - |
Rattus norvegicus | ? | - |
? | |
propiophenone + NADPH | - |
Rattus norvegicus | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme does not contain flavin | Rattus norvegicus | |
NADPH | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00009 | - |
IC50 0.00009 mM | Rattus norvegicus | Hg2+ | |
0.0006 | - |
IC50 0.0006 mM | Rattus norvegicus | dicoumarol | |
0.0006 | - |
IC50 0.0006 mM | Rattus norvegicus | N-acetylserotonin | |
0.03 | - |
IC50 0.03 mM | Rattus norvegicus | Ethacrynic acid | |
0.03 | - |
IC50 0.03 mM | Rattus norvegicus | 6-Carboxypterin | |
0.06 | - |
IC50 0.06 mM | Rattus norvegicus | indomethacin | |
0.06 | - |
IC50 0.06 mM | Rattus norvegicus | rutin | |
0.1 | - |
IC50 0.1 mM | Rattus norvegicus | Cd2+ | |
0.3 | - |
IC50 0.3 mM, pH 6.4 | Rattus norvegicus | propionic acid | |
0.4 | - |
IC50 0.4 mM | Rattus norvegicus | Zn2+ | |
0.6 | - |
slight, IC50 0.6 mM | Rattus norvegicus | Phenobarbital | |
1 | - |
slight, IC50 1 mM | Rattus norvegicus | pyrazole | |
5 | - |
slight, IC50 5 mM | Rattus norvegicus | alpha-ketoglutarate |