Application | Comment | Organism |
---|---|---|
biotechnology | a process is developed that that allows the production of 20alpha- dihydrodydrogesterone at technical scale (several grams of 20a-DHD per week and fermenter). Genetic improvement of the production strain, an increase of substrate solubility by addition of ß-cyclodextrin, and the development of a sophisticated high-cell density fermentation at pilot scale are employed. By usage of the exemplary substrate progesterone, it is hsown that this innovative fission yeast-based whole cell biotransformation process is transferable to the conversion of other AKR1C1 substrates without special adaptation | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
recombinantly expressed in fission yeast cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
progesterone + NADH | - |
Homo sapiens | 20alpha-hydroxyprogesterone + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
20alpha-HSD | - |
Homo sapiens |
20alpha-hydroxysteroid dehydrogenase | - |
Homo sapiens |
AKR1C1 | - |
Homo sapiens |