Crystallization (Comment) | Organism |
---|---|
ternary complex with NADP+ and 20alpha-hydroxyprogesterone | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D309L | similar Km-value as wild-type | Homo sapiens |
E127D | increase in Km-value | Homo sapiens |
H222I | dramatic increase in Km-value | Homo sapiens |
H222S | large increase in Km-value | Homo sapiens |
R304L | dramatic increase in Km-value | Homo sapiens |
T307V | similar Km-value as wild-type | Homo sapiens |
Y305F | similar Km-value as wild-type | Homo sapiens |
Y55F | no enzymic activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | - |
NADPH | wild type, pH 7.5, 37°C | Homo sapiens | |
0.00117 | - |
20alpha-hydroxyprogesterone | wild type, pH 7.5, 37°C | Homo sapiens | |
0.0021 | - |
NADPH | mutant H222S, pH 7.5, 37°C | Homo sapiens | |
0.0041 | - |
progesterone | mutant T307V, pH 7.5, 37°C | Homo sapiens | |
0.0042 | - |
progesterone | wild type, pH 7.5, 37°C | Homo sapiens | |
0.0046 | - |
progesterone | mutant D309L, pH 7.5, 37°C | Homo sapiens | |
0.0056 | - |
progesterone | mutant Y305F, pH 7.5, 37°C | Homo sapiens | |
0.0094 | - |
progesterone | mutant E127D, pH 7.5, 37°C | Homo sapiens | |
0.019 | - |
NADPH | mutant H222S, pH 7.5, 37°C | Homo sapiens | |
0.0256 | - |
progesterone | mutant H222S, pH 7.5, 37°C | Homo sapiens | |
0.0286 | - |
progesterone | mutant H222I, pH 7.5, 37°C | Homo sapiens | |
0.069 | - |
dihydrotestosterone | wild type, pH 7.5, 37°C | Homo sapiens | |
0.098 | - |
20alpha-hydroxyprogesterone | mutant H222I, pH 7.5, 37°C | Homo sapiens | |
0.151 | - |
dihydrotestosterone | mutant R304L, pH 7.5, 37°C | Homo sapiens | |
0.1774 | - |
20alpha-hydroxyprogesterone | mutant H222S, pH 7.5, 37°C | Homo sapiens | |
0.2833 | - |
progesterone | mutant R304L, pH 7.5, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
20alpha-hydroxyprogesterone + NADP+ | - |
Homo sapiens | progesterone + NADPH | - |
r | |
dihydrotestosterone + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
progesterone + NADPH | - |
Homo sapiens | 20alpha-hydroxyprogesterone + NADP+ | - |
r |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |