Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(-)-catechin | about 98% activity at 0.2 mM | Homo sapiens | |
(-)-epicatechin | about 95% activity at 0.2 mM | Homo sapiens | |
(-)-epigallocatechin | less than 80% activity at 0.2 mM | Homo sapiens | |
(-)-epigallocatechin 3-gallate | potent inhibitor, less than 10% activity at 0.2 mM | Homo sapiens | |
(-)-gallocatechin | less than 30% activity at 0.2 mM | Homo sapiens | |
additional information | tea extracts inhibit isoform 11beta-HSD1 mediated cortisone reduction, where green tea exhibits the highest inhibitory potency with an IC50 value of 3.749 mg dried tea leaves per ml | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | Homo sapiens | - |
cortisol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28845 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01874 | - |
(-)-epigallocatechin 3-gallate | purified enzyme, at pH 7.4 and 37°C | Homo sapiens | |
0.02268 | - |
(-)-epigallocatechin 3-gallate | unpurified enzyme, at pH 7.4 and 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.05799 | - |
for cortisone reduction, at pH 7.4 and 37°C | Homo sapiens | (-)-epigallocatechin 3-gallate | |
0.1312 | - |
for cortisol oxidation, at pH 7.4 and 37°C | Homo sapiens | (-)-epigallocatechin 3-gallate |