Literature summary for 1.1.1.146 extracted from

De Sousa Peixoto, R.A.; Turban, S.; Battle, J.H.; Chapman, K.E.; Seckl, J.R.; Morton, N.M.
Preadipocyte 11beta-hydroxysteroid dehydrogenase type 1 is a keto-reductase and contributes to diet-induced visceral obesity in vivo (2008), Endocrinology, 149, 1861-1868.

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Application

Application	Comment	Organism
medicine	high-fat diet-induced obesity is accompanied by increased visceral fat preadipocyte differentiation in wild-type but not 11beta-HSD1 -/- mice	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adipose tissue	isoform 11beta-HSD1 is highly expressed in freshly isolated omental adipose stromal vascular cells, predominantly in preadipocytes. The enzxyme acts as an 11beta-reduxtase, reactivating glucocorticoids. Glucocorticoid reactivation is higher in intact mesenteric cells than in thigh and axillary depots	Mus musculus	-
preadipocyte	isoform 11beta-HSD1 is highly expressed in freshly isolated omental adipose stromal vascular cells, predominantly in preadipocytes	Mus musculus	-
vascular cell	-	Mus musculus	-

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Release 2023.1 (January 2023)