Literature summary for 1.1.1.146 extracted from

Su, X.; Vicker, N.; Ganeshapillai, D.; Smith, A.; Purohit, A.; Reed, M.J.; Potter, B.V.
Benzothiazole derivatives as novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1 (2006), Mol. Cell. Endocrinol., 248, 214-217.

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Application

Application	Comment	Organism
drug development	isozyme 11beta-HSD1 is a target in treatment of metabolic diseases such as diabetes mellitus type 2 or obesity	Homo sapiens
pharmacology	isozyme 11beta-HSD1 is a target in treatment of metabolic diseases such as diabetes mellitus type 2 or obesity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
benzothiazole derivatives	specific inhibition of isozyme 11beta-HSD1, inhibitory potency and IC50 values, overview, structure-activity relationship, introduction of a chlor atom at position 4 greatly enhances the inhibitory activity, inhibitory mechanism and enzyme/cofactor interaction analysis from molecular docking studies	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozyme 11beta-HSD1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
11beta-HSD1	-	Homo sapiens
11beta-hydroxysteroid dehydrogenase type 1	-	Homo sapiens

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Release 2023.1 (January 2023)