Cloned (Comment) | Organism |
---|---|
stable expression of isozymes 11beta-HSD1 and 11beta-HSD2 in CHO cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(5-oxo-2,5-dihydrofuran-3-yl)urea | specific for isozyme 11beta-HSD1 | Homo sapiens | |
arylsulfonamidothiazole derivatives | specific for isozyme 11beta-HSD1 | Homo sapiens | |
BVT-14225 | isozyme 11beta-HSD1 IC50: 52 nM, 1000fold less potent against isozyme 11beta-HSD2 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | Homo sapiens | isozyme 11beta-HSD1 catalyzes the forward reaction with cofactor NADPH | cortisol + NADP+ | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes 11beta-HSD1 and 11beta-HSD2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | isozyme 11beta-HSD1 catalyzes the forward reaction with cofactor NADPH | Homo sapiens | cortisol + NADP+ | - |
ir |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000052 | - |
isozyme 11beta-HSD1 IC50: 52 nM, 1000fold less potent against isozyme 11beta-HSD2, pH and temperature not specified in the publication | Homo sapiens | BVT-14225 |