Cloned (Comment) | Organism |
---|---|
cloning of cDNA | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
glycyrrhetinic acid | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.014 | - |
cortisone | 37°C, pH 7.4, Hill coefficient of 1.6 | Homo sapiens | |
0.02 | - |
dehydrocorticosterone | 37°C, pH 7.4, Hill coefficient of 2.7 | Homo sapiens | |
0.041 | - |
cortisol | 37°C, pH 7.4, Hill coefficient of 1.0, no cooperative kinetic | Homo sapiens | |
0.043 | - |
corticosterone | 37°C, pH 7.4, Hill coefficient of 0.7 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
membrane | membrane bound | Homo sapiens | 16020 | - |
microsome | - |
Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32386 | - |
2 * 32386, deduced from nucleotide sequence | Homo sapiens |
34000 | - |
2 * 34000, SDS-PAGE | Homo sapiens |
67400 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | Homo sapiens | primarly a reductase in vivo | cortisol + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Purification (Comment) | Organism |
---|---|
solubilized microsomes, octyl-Sepharose, Mono Q-Sepharose, Red Sepharose A | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
91.36 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
r | |
cortisone + NADPH + H+ | primarly a reductase in vivo | Homo sapiens | cortisol + NADP+ | - |
r | |
dehydrocorticosterone + NADPH | - |
Homo sapiens | corticosterone + NADP+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 34000, SDS-PAGE | Homo sapiens |
dimer | 2 * 32386, deduced from nucleotide sequence | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000049 | - |
glycyrrhetinic acid | 37°C, pH 9.0, inhibition of cortisol oxidation | Homo sapiens | |
0.000014 | - |
glycyrrhetinic acid | 37°C, pH 9.0, inhibition of cortisone reduction | Homo sapiens |