Literature summary for 1.1.1.146 extracted from

Ozols, J.
Lumenal orientation and post-translational modifications of the liver microsomal 11beta-hydroxysteroid dehydrogenase (1995), J. Biol. Chem., 270, 2305-2312.

Search for more literature for 1.1.1.146

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
35000	-	x * 35000, SDS-PAGE	Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+	Oryctolagus cuniculus	-	21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	rabbit	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	high-mannose carbohydrates at Asn-122, Asn-161, Asn-206	Oryctolagus cuniculus
additional information	one disulfide bond linking Cys-77 and Cys-212	Oryctolagus cuniculus

Purification (Commentary)

Purification (Comment)	Organism
to homogeneity, chromatography techniques	Oryctolagus cuniculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+	-	Oryctolagus cuniculus	21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+	-	?

Subunits

Subunits	Comment	Organism
?	x * 35000, SDS-PAGE	Oryctolagus cuniculus

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Oryctolagus cuniculus

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Release 2023.1 (January 2023)