Application | Comment | Organism |
---|---|---|
medicine | in aldosterone-producing adenoma, isoform HSD3B2 mRNA is significantly more abundant than HSD3B1 mRNA, but only HSD3B1 mRNA significantly correlates with CYP11B2 (aldosterone synthase) mRNA and plasma aldosterone concentration of the patients. A significant correlation is also detected between isoform HSD3B1 and CYP11B2. In KCNJ5 mutated aldosterone-producing adenoma, CYP11B2 mRNA and HSD3B1 mRNA are significantly higher than those of wild-type aldosterone-producing adenoma | Homo sapiens |
medicine | in aldosterone-producing adenoma, isoform HSD3B2 mRNA is significantly more abundant than HSD3B1 mRNA, but only HSD3B1 mRNA significantly correlates with CYP11B2 (aldosterone synthase) mRNA and plasma aldosterone concentration of the patients. Isoform HSD3B2 immunoreactivity is detected in the great majority of aldosterone-producing adenoma | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone + NAD+ | Homo sapiens | - |
androst-5-en-3,17-dione + NADH + H+ | - |
? | |
pregnenolone + NAD+ | Homo sapiens | - |
pregn-5-en-3,20-dione + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P26439 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adenoma cell | - |
Homo sapiens | - |
adrenal gland | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone + NAD+ | - |
Homo sapiens | androst-5-en-3,17-dione + NADH + H+ | - |
? | |
pregnenolone + NAD+ | - |
Homo sapiens | pregn-5-en-3,20-dione + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3-beta-hydroxysteroid dehydrogenase | - |
Homo sapiens |
HSD3B1 | - |
Homo sapiens |
HSD3B1 | isoform | Homo sapiens |
HSD3B2 | - |
Homo sapiens |
HSD3B2 | isoform | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | isoform HSD3B1 is involved in aldosterone production in aldosterone-producing adenoma | Homo sapiens |