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Literature summary for 1.1.1.145 extracted from

  • Yang, G.; Dou, J.; Zhang, X.; Gu, W.; Lv, Z.; DU, J.; Ba, J.; Mu, Y.; Lu, J.
    Increased 3beta-hydroxysteroid dehydrogenase 2 and 17beta-hydroxylase activities in a virilized adolescent female with adrenal adenoma: A case report (2016), Exp. Ther. Med., 11, 530-534.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine in a female patient with pseudo-hermaphrodism caused by an androgen-producing adrenocortical tumor. The activities of 3beta-hydroxysteroid dehydrogenase 2 and CYP17 in the tumor tissue are higher than those in the normal tissue, whereas the activity of 17beta?hydroxysteroid dehydrogenase 3 is lower. The mRNA levels of 3beta-hydroxysteroid dehydrogenase 2 and CYP17 are higher and the levels of 17beta-hydroxysteroid dehydrogenase 3 and LH/hCG receptor are lower in the tumor tissue compared with those of the normal tissue Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal adenoma cell
-
Homo sapiens
-
adrenal gland
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
3beta-hydroxysteroid dehydrogenase 2
-
Homo sapiens
HSD2
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the mRNA level of the enzyme is higher in tumor tissue compared with those of the normal tissue up