Literature summary for 1.1.1.145 extracted from

Nakamura, Y.; Xing, Y.; Hui, X.G.; Kurotaki, Y.; Ono, K.; Cohen, T.; Sasano, H.; Rainey, W.E.
Human adrenal cells that express both 3?-hydroxysteroid dehydrogenase type 2 (HSD3B2) and cytochrome b5 (CYB5A) contribute to adrenal androstenedione production (2011), J. Steroid Biochem. Mol. Biol., 123, 122-126.

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Inhibitors

Inhibitors	Comment	Organism	Structure
trilostane	human adrenal H295R cells treated with the HSD3B2 inhibitor, trilostane, demonstrate a markedly decreased androstenedione production	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adrenal gland	HSD3B2 and CYB5A are immonolocalized in normal human adrenal glands. Their co-expression is demonstrated in the cortical cells located at the border between the zona fasciculata and zona reticularis in normal human adrenal	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
3beta-hydroxysteroid dehydrogenase type 2	-	Homo sapiens
HSD3B2	-	Homo sapiens

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Release 2023.1 (January 2023)