Literature summary for 1.1.1.145 extracted from

Ernst, M.; de Padua, R.M.; Herl, V.; Mueller-Uri, F.; Kreis, W.
Expression of 3beta-HSD and P5betaR, genes respectively coding for Delta5-3beta-hydroxysteroid dehydrogenase and progesterone 5beta-reductase, in leaves and cell cultures of Digitalis lanata EHRH (2010), Planta Med., 76, 923-927.

Search for more literature for 1.1.1.145

Organism

Organism	UniProt	Comment	Textmining
Digitalis lanata	Q93Y47	-	-
Digitalis lanata EHRH	Q93Y47	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cell suspension culture	cardenolide-free cell suspension culture	Digitalis lanata	-
leaf	cardenolide-accumulating leaf	Digitalis lanata	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme catalyzes at least two reactions in the cardenolide pathway, i.e. dehydrogenation of pregnenolone to isoprogesterone and the reduction of 5beta-pregnane-3,20-dione to 5beta-pregnan-3beta-ol-20-one. Recombinant enzyme displays 3alpha-, 3beta- and 17beta-dehydrogenase as well as 3/17-keto reductase activities	Digitalis lanata	?	-	?
additional information	enzyme catalyzes at least two reactions in the cardenolide pathway, i.e. dehydrogenation of pregnenolone to isoprogesterone and the reduction of 5beta-pregnane-3,20-dione to 5beta-pregnan-3beta-ol-20-one. Recombinant enzyme displays 3alpha-, 3beta- and 17beta-dehydrogenase as well as 3/17-keto reductase activities	Digitalis lanata EHRH	?	-	?
pregnenolone + NAD+	-	Digitalis lanata	isoprogesterone + NADH + H+	-	?
pregnenolone + NAD+	-	Digitalis lanata EHRH	isoprogesterone + NADH + H+	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)