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Literature summary for 1.1.1.145 extracted from

  • Thomas, J.L.; Bucholtz, K.M.; Sun, J.; Mack, V.L.; Kacsoh, B.
    Structural basis for the selective inhibition of human 3beta-hydroxysteroid dehydrogenase 1 in human breast tumor MCF-7 cells (2009), Mol. Cell. Endocrinol., 301, 174-182.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
17beta-acetoxy-trilostane
-
Homo sapiens
epostane competitive inhibition Homo sapiens
trilostane i.e. 2alpha-cyano-4alpha,5alpha-epoxy-17beta-ol-androstane-3-one, competitive inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0037
-
dehydroepiandrosterone in 0.02 M potassium phosphate buffer, pH 7.4 Homo sapiens
0.0341
-
NAD+ in 0.02 M potassium phosphate buffer, pH 7.4 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dehydroepiandrosterone + NAD+
-
Homo sapiens androst-5-en-3,17-dione + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
3beta-HSD1
-
Homo sapiens
3beta-hydroxysteroid dehydrogenase 1
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.055
-
dehydroepiandrosterone in 0.02 M potassium phosphate buffer, pH 7.4 Homo sapiens
0.058
-
NAD+ in 0.02 M potassium phosphate buffer, pH 7.4 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0001
-
trilostane in 0.02 M potassium phosphate buffer, pH 7.4 Homo sapiens
0.00043
-
17beta-acetoxy-trilostane in 0.02 M potassium phosphate buffer, pH 7.4 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0002
-
in 0.02 M potassium phosphate buffer, pH 7.4 Homo sapiens epostane
0.0049
-
in 0.02 M potassium phosphate buffer, pH 7.4 Homo sapiens trilostane