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Literature summary for 1.1.1.145 extracted from

  • Matsunaga, T.; Endo, S.; Maeda, S.; Ishikura, S.; Tajima, K.; Tanaka, N.; Nakamura, K.T.; Imamura, Y.; Hara, A.
    Characterization of human DHRS4: An inducible short-chain dehydrogenase/reductase enzyme with 3beta-hydroxysteroid dehydrogenase activity (2008), Arch. Biochem. Biophys., 477, 339-347.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
T177N significantly improved stability at cold temperature, presence of NAD+ is required for complete stability at 0°C Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Cetylpyridinium chloride
-
Homo sapiens
genistein
-
Homo sapiens
lauric acid 0.05 mM, less than 10% inhibition Homo sapiens
myristic acid 0.05 mM, less than 10% inhibition Homo sapiens
phenylhexane
-
Homo sapiens
quercetin
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0003
-
NADPH pH 7.4, 25°C Homo sapiens
0.0003
-
NADP+ pH 7.4, 25°C Homo sapiens
0.0015
-
4,4'-dimethylbenzil pH 7.4, 25°C Homo sapiens
0.0029
-
5beta-pregnane-3,20-dione pH 7.4, 25°C Homo sapiens
0.0036
-
9,10-phenanthrenequinone pH 7.4, 25°C Homo sapiens
0.0041
-
5beta-androstane-3beta,17beta-diol pH 7.4, 25°C Homo sapiens
0.0049
-
5beta-androstan-17beta-ol-3-one pH 7.4, 25°C Homo sapiens
0.005
-
benzil pH 7.4, 25°C Homo sapiens
0.0052
-
1-phenylisatin pH 7.4, 25°C Homo sapiens
0.0079
-
5beta-androstan-3beta-ol-17-one pH 7.4, 25°C Homo sapiens
0.008
-
5beta-Pregnan-3beta-ol-20-one pH 7.4, 25°C Homo sapiens
0.008
-
5beta-pregnane-3beta,20alpha-diol pH 7.4, 25°C Homo sapiens
0.0084
-
(S)-phenyl-1-butanol pH 7.4, 25°C Homo sapiens
0.0097
-
5beta-pregnan-20alpha-ol-3-one pH 7.4, 25°C Homo sapiens
0.01
-
5beta-androstane-3,17-dione pH 7.4, 25°C Homo sapiens
0.016
-
5alpha-dihydrotestosterone pH 7.4, 25°C Homo sapiens
0.024
-
all-trans-retinal pH 7.4, 25°C Homo sapiens
0.028
-
5alpha-androstane-3,17-dione pH 7.4, 25°C Homo sapiens
0.035
-
Dehydrolithocholic acid pH 7.4, 25°C Homo sapiens
0.036
-
hexanophenone pH 7.4, 25°C Homo sapiens
0.048
-
n-butyrophenone pH 7.4, 25°C Homo sapiens
0.054
-
valerophenone pH 7.4, 25°C Homo sapiens
0.089
-
1,4-Naphthoquinone pH 7.4, 25°C Homo sapiens
0.093
-
(S)-1-tetralol pH 7.4, 25°C Homo sapiens
0.12
-
6-tert-butyl-2,3-epoxy-5-cyclohexene-1,4-dione pH 7.4, 25°C Homo sapiens
0.16
-
4-hexanoylpyridine pH 7.4, 25°C Homo sapiens
0.18
-
menadione pH 7.4, 25°C Homo sapiens
0.2
-
2,3-heptanedione pH 7.4, 25°C Homo sapiens
0.24
-
(S)-1-indanol pH 7.4, 25°C Homo sapiens
0.32
-
isatin pH 7.4, 25°C Homo sapiens
0.55
-
2,3-Hexanedione pH 7.4, 25°C Homo sapiens
1
-
4-benzoylpyridine pH 7.4, 25°C Homo sapiens
1.4
-
dimethyl-2-oxo-glutarate pH 7.4, 25°C Homo sapiens
10
-
2,3-Pentanedione pH 7.4, 25°C Homo sapiens
13
-
4-nitrobenzaldehyde pH 7.4, 25°C Homo sapiens
21
-
Pyridine-4-aldehyde pH 7.4, 25°C Homo sapiens
54
-
diacetyl pH 7.4, 25°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isoform DHRS4
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell induction by peroxisome-proliferator-activated receptor alpha ligands Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-1-indanol + NADP+
-
Homo sapiens ? + NADPH
-
r
(S)-1-tetralol + NADP+
-
Homo sapiens ? + NADPH
-
r
(S)-phenyl-1-butanol + NADP+
-
Homo sapiens ? + NADPH
-
r
1,4-naphthoquinone + NADPH + H+
-
Homo sapiens ? + NADP+
-
r
1-phenylisatin + NADPH
-
Homo sapiens ? + NADP+
-
r
2,3-heptanedione + NADPH
-
Homo sapiens ? + NADP+
-
r
2,3-hexanedione + NADPH
-
Homo sapiens ? + NADP+
-
r
2,3-pentanedione + NADPH + H+
-
Homo sapiens ? + NADP+
-
r
4,4'-dimethylbenzil + NADPH
-
Homo sapiens ? + NADP+
-
r
4-benzoylpyridine + NADPH
-
Homo sapiens ? + NADP+
-
r
4-hexanoylpyridine + NADPH
-
Homo sapiens ? + NADP+
-
r
4-nitrobenzaldehyde + NADPH
-
Homo sapiens ? + NADP+
-
r
5alpha-androstan-3beta-ol-17-one + NADP+
-
Homo sapiens 5alpha-androstan-3,17-dione + NADPH
-
r
5alpha-androstane-3,17-dione + NADPH
-
Homo sapiens 5alpha-androstane-3beta-ol-17-one + NADP+
-
r
5alpha-androstane-3beta,17beta-diol + NADP+
-
Homo sapiens 5alpha-androstane-17beta-ol-3-one + NADPH
-
r
5alpha-dihydrotestosterone + NADPH
-
Homo sapiens ? + NADP+
-
r
5alpha-pregnane-3beta-ol-20-one + NADP+
-
Homo sapiens 5alpha-pregnane-3,20-dione + NADPH
-
r
5beta-androstan-17beta-ol-3-one + NADPH
-
Homo sapiens 5beta-androstane-3beta,17beta-diol + NADP+
-
r
5beta-androstan-3beta-ol-17-one + NADP+
-
Homo sapiens 5beta-androstane-3,17-dione + NADPH
-
r
5beta-androstane-3,17-dione + NADPH
-
Homo sapiens 5beta-androstan-3beta-ol-17-one + NADP+
-
r
5beta-androstane-3beta,17beta-diol + NADP+
-
Homo sapiens 5beta-androstan-17beta-ol-3-one + NADPH
-
r
5beta-pregnan-20alpha-ol-3-one + NADPH + H+
-
Homo sapiens 5beta-pregnan-3beta,20alpha-diol + NADP+
-
r
5beta-pregnan-3beta-ol-20-one + NADP+
-
Homo sapiens 5beta-pregnan-3,20-dione + NADPH
-
r
5beta-pregnane-3,20-dione + NADPH + H+
-
Homo sapiens 5beta-pregnan-3beta-ol-20-one + NADP+
-
r
5beta-pregnane-3beta,20alpha-diol + NADP+
-
Homo sapiens 5beta-pregnane-20alpha-ol-3-one + NADPH + H+
-
r
6-tert-butyl-2,3-epoxy-5-cyclohexene-1,4-dione + NADPH major product has S-configuration Homo sapiens ? + NADP+
-
r
9,10-phenanthrenequinone + NADPH
-
Homo sapiens ? + NADP+
-
r
all-trans-retinal + NADPH
-
Homo sapiens ? + NADP+
-
r
all-trans-retinol + NADP+
-
Homo sapiens ? + NADPH
-
r
benzil + NADPH enantiomeric purity of 97% enantiomeric excess Homo sapiens (R)-benzoin + NADP+
-
r
dehydrolithocholic acid + NADPH
-
Homo sapiens isolithocholic acid + NADP+
-
r
diacetyl + NADPH
-
Homo sapiens ? + NADP+
-
r
dimethyl-2-oxo-glutarate + NADPH
-
Homo sapiens ? + NADP+
-
r
hexanophenone + NADPH
-
Homo sapiens ? + NADP+
-
r
isatin + NADPH
-
Homo sapiens ? + NADP+
-
r
isolithocholic acid + NADP+
-
Homo sapiens dehydrolithocholic acid + NADPH
-
r
menadione + NADPH
-
Homo sapiens ? + NADP+
-
r
additional information enzyme exhibits high stereo-selectivity yielding 3-beta-hydroxysteroids from 3-ketosteroids Homo sapiens ?
-
?
n-butyrophenone + NADPH major product Homo sapiens (S)-1-phenyl1-butanol + NADP+
-
r
pyridine-4-aldehyde + NADPH
-
Homo sapiens ? + NADP+
-
r
testosterone + NADPH + H+
-
Homo sapiens ? + NADP+
-
r
valerophenone + NADPH
-
Homo sapiens ? + NADP+
-
r

Synonyms

Synonyms Comment Organism
DHRS4
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.014
-
5beta-pregnane-3beta,20alpha-diol pH 7.4, 25°C Homo sapiens
0.017
-
5beta-androstan-3beta-ol-17-one pH 7.4, 25°C Homo sapiens
0.017
-
5beta-androstane-3beta,17beta-diol pH 7.4, 25°C Homo sapiens
0.041
-
5beta-Pregnan-3beta-ol-20-one pH 7.4, 25°C Homo sapiens
0.043
-
Dehydrolithocholic acid pH 7.4, 25°C Homo sapiens
0.05
-
all-trans-retinal pH 7.4, 25°C Homo sapiens
0.063
-
5beta-pregnane-3,20-dione pH 7.4, 25°C Homo sapiens
0.07
-
5beta-pregnan-20alpha-ol-3-one pH 7.4, 25°C Homo sapiens
0.075
-
(S)-phenyl-1-butanol pH 7.4, 25°C Homo sapiens
0.077
-
5beta-androstane-3,17-dione pH 7.4, 25°C Homo sapiens
0.083
-
5beta-androstan-17beta-ol-3-one pH 7.4, 25°C Homo sapiens
0.095
-
5alpha-dihydrotestosterone pH 7.4, 25°C Homo sapiens
0.097
-
5alpha-androstane-3,17-dione pH 7.4, 25°C Homo sapiens
0.18
-
(S)-1-indanol pH 7.4, 25°C Homo sapiens
0.25
-
(S)-1-tetralol pH 7.4, 25°C Homo sapiens
0.65
-
menadione pH 7.4, 25°C Homo sapiens
0.85
-
n-butyrophenone pH 7.4, 25°C Homo sapiens
0.88
-
1,4-Naphthoquinone pH 7.4, 25°C Homo sapiens
2
-
4-benzoylpyridine pH 7.4, 25°C Homo sapiens
2
-
valerophenone pH 7.4, 25°C Homo sapiens
2
-
6-tert-butyl-2,3-epoxy-5-cyclohexene-1,4-dione pH 7.4, 25°C Homo sapiens
2.7
-
hexanophenone pH 7.4, 25°C Homo sapiens
3.7
-
4,4'-dimethylbenzil pH 7.4, 25°C Homo sapiens
4.7
-
Pyridine-4-aldehyde pH 7.4, 25°C Homo sapiens
11.8
-
9,10-phenanthrenequinone pH 7.4, 25°C Homo sapiens
16.3
-
2,3-Hexanedione pH 7.4, 25°C Homo sapiens
16.7
-
4-nitrobenzaldehyde pH 7.4, 25°C Homo sapiens
26.7
-
2,3-Pentanedione pH 7.4, 25°C Homo sapiens
28.3
-
diacetyl pH 7.4, 25°C Homo sapiens
31.7
-
isatin pH 7.4, 25°C Homo sapiens
31.7
-
benzil pH 7.4, 25°C Homo sapiens
33.3
-
4-hexanoylpyridine pH 7.4, 25°C Homo sapiens
33.3
-
dimethyl-2-oxo-glutarate pH 7.4, 25°C Homo sapiens
40.2
-
2,3-heptanedione pH 7.4, 25°C Homo sapiens
41.7
-
1-phenylisatin pH 7.4, 25°C Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
dimethyl-2-oxoglutarate reductase activity Homo sapiens
6.5 10 broad, S-1-tetralol dehydrogenase activity Homo sapiens

Cofactor

Cofactor Comment Organism Structure
additional information no significant activity with NAD+/NADH Homo sapiens
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0027
-
pH 7.4, 25°C Homo sapiens quercetin
0.0059
-
pH 7.4, 25°C Homo sapiens genistein
0.0066
-
pH 7.4, 25°C Homo sapiens Cetylpyridinium chloride
0.023
-
pH 7.4, 25°C Homo sapiens phenylhexane