Protein Variants | Comment | Organism |
---|---|---|
T177N | significantly improved stability at cold temperature, presence of NAD+ is required for complete stability at 0°C | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cetylpyridinium chloride | - |
Homo sapiens | |
genistein | - |
Homo sapiens | |
lauric acid | 0.05 mM, less than 10% inhibition | Homo sapiens | |
myristic acid | 0.05 mM, less than 10% inhibition | Homo sapiens | |
phenylhexane | - |
Homo sapiens | |
quercetin | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0003 | - |
NADPH | pH 7.4, 25°C | Homo sapiens | |
0.0003 | - |
NADP+ | pH 7.4, 25°C | Homo sapiens | |
0.0015 | - |
4,4'-dimethylbenzil | pH 7.4, 25°C | Homo sapiens | |
0.0029 | - |
5beta-pregnane-3,20-dione | pH 7.4, 25°C | Homo sapiens | |
0.0036 | - |
9,10-phenanthrenequinone | pH 7.4, 25°C | Homo sapiens | |
0.0041 | - |
5beta-androstane-3beta,17beta-diol | pH 7.4, 25°C | Homo sapiens | |
0.0049 | - |
5beta-androstan-17beta-ol-3-one | pH 7.4, 25°C | Homo sapiens | |
0.005 | - |
benzil | pH 7.4, 25°C | Homo sapiens | |
0.0052 | - |
1-phenylisatin | pH 7.4, 25°C | Homo sapiens | |
0.0079 | - |
5beta-androstan-3beta-ol-17-one | pH 7.4, 25°C | Homo sapiens | |
0.008 | - |
5beta-Pregnan-3beta-ol-20-one | pH 7.4, 25°C | Homo sapiens | |
0.008 | - |
5beta-pregnane-3beta,20alpha-diol | pH 7.4, 25°C | Homo sapiens | |
0.0084 | - |
(S)-phenyl-1-butanol | pH 7.4, 25°C | Homo sapiens | |
0.0097 | - |
5beta-pregnan-20alpha-ol-3-one | pH 7.4, 25°C | Homo sapiens | |
0.01 | - |
5beta-androstane-3,17-dione | pH 7.4, 25°C | Homo sapiens | |
0.016 | - |
5alpha-dihydrotestosterone | pH 7.4, 25°C | Homo sapiens | |
0.024 | - |
all-trans-retinal | pH 7.4, 25°C | Homo sapiens | |
0.028 | - |
5alpha-androstane-3,17-dione | pH 7.4, 25°C | Homo sapiens | |
0.035 | - |
Dehydrolithocholic acid | pH 7.4, 25°C | Homo sapiens | |
0.036 | - |
hexanophenone | pH 7.4, 25°C | Homo sapiens | |
0.048 | - |
n-butyrophenone | pH 7.4, 25°C | Homo sapiens | |
0.054 | - |
valerophenone | pH 7.4, 25°C | Homo sapiens | |
0.089 | - |
1,4-Naphthoquinone | pH 7.4, 25°C | Homo sapiens | |
0.093 | - |
(S)-1-tetralol | pH 7.4, 25°C | Homo sapiens | |
0.12 | - |
6-tert-butyl-2,3-epoxy-5-cyclohexene-1,4-dione | pH 7.4, 25°C | Homo sapiens | |
0.16 | - |
4-hexanoylpyridine | pH 7.4, 25°C | Homo sapiens | |
0.18 | - |
menadione | pH 7.4, 25°C | Homo sapiens | |
0.2 | - |
2,3-heptanedione | pH 7.4, 25°C | Homo sapiens | |
0.24 | - |
(S)-1-indanol | pH 7.4, 25°C | Homo sapiens | |
0.32 | - |
isatin | pH 7.4, 25°C | Homo sapiens | |
0.55 | - |
2,3-Hexanedione | pH 7.4, 25°C | Homo sapiens | |
1 | - |
4-benzoylpyridine | pH 7.4, 25°C | Homo sapiens | |
1.4 | - |
dimethyl-2-oxo-glutarate | pH 7.4, 25°C | Homo sapiens | |
10 | - |
2,3-Pentanedione | pH 7.4, 25°C | Homo sapiens | |
13 | - |
4-nitrobenzaldehyde | pH 7.4, 25°C | Homo sapiens | |
21 | - |
Pyridine-4-aldehyde | pH 7.4, 25°C | Homo sapiens | |
54 | - |
diacetyl | pH 7.4, 25°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform DHRS4 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | induction by peroxisome-proliferator-activated receptor alpha ligands | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-1-indanol + NADP+ | - |
Homo sapiens | ? + NADPH | - |
r | |
(S)-1-tetralol + NADP+ | - |
Homo sapiens | ? + NADPH | - |
r | |
(S)-phenyl-1-butanol + NADP+ | - |
Homo sapiens | ? + NADPH | - |
r | |
1,4-naphthoquinone + NADPH + H+ | - |
Homo sapiens | ? + NADP+ | - |
r | |
1-phenylisatin + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
2,3-heptanedione + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
2,3-hexanedione + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
2,3-pentanedione + NADPH + H+ | - |
Homo sapiens | ? + NADP+ | - |
r | |
4,4'-dimethylbenzil + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
4-benzoylpyridine + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
4-hexanoylpyridine + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
4-nitrobenzaldehyde + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
5alpha-androstan-3beta-ol-17-one + NADP+ | - |
Homo sapiens | 5alpha-androstan-3,17-dione + NADPH | - |
r | |
5alpha-androstane-3,17-dione + NADPH | - |
Homo sapiens | 5alpha-androstane-3beta-ol-17-one + NADP+ | - |
r | |
5alpha-androstane-3beta,17beta-diol + NADP+ | - |
Homo sapiens | 5alpha-androstane-17beta-ol-3-one + NADPH | - |
r | |
5alpha-dihydrotestosterone + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
5alpha-pregnane-3beta-ol-20-one + NADP+ | - |
Homo sapiens | 5alpha-pregnane-3,20-dione + NADPH | - |
r | |
5beta-androstan-17beta-ol-3-one + NADPH | - |
Homo sapiens | 5beta-androstane-3beta,17beta-diol + NADP+ | - |
r | |
5beta-androstan-3beta-ol-17-one + NADP+ | - |
Homo sapiens | 5beta-androstane-3,17-dione + NADPH | - |
r | |
5beta-androstane-3,17-dione + NADPH | - |
Homo sapiens | 5beta-androstan-3beta-ol-17-one + NADP+ | - |
r | |
5beta-androstane-3beta,17beta-diol + NADP+ | - |
Homo sapiens | 5beta-androstan-17beta-ol-3-one + NADPH | - |
r | |
5beta-pregnan-20alpha-ol-3-one + NADPH + H+ | - |
Homo sapiens | 5beta-pregnan-3beta,20alpha-diol + NADP+ | - |
r | |
5beta-pregnan-3beta-ol-20-one + NADP+ | - |
Homo sapiens | 5beta-pregnan-3,20-dione + NADPH | - |
r | |
5beta-pregnane-3,20-dione + NADPH + H+ | - |
Homo sapiens | 5beta-pregnan-3beta-ol-20-one + NADP+ | - |
r | |
5beta-pregnane-3beta,20alpha-diol + NADP+ | - |
Homo sapiens | 5beta-pregnane-20alpha-ol-3-one + NADPH + H+ | - |
r | |
6-tert-butyl-2,3-epoxy-5-cyclohexene-1,4-dione + NADPH | major product has S-configuration | Homo sapiens | ? + NADP+ | - |
r | |
9,10-phenanthrenequinone + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
all-trans-retinal + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
all-trans-retinol + NADP+ | - |
Homo sapiens | ? + NADPH | - |
r | |
benzil + NADPH | enantiomeric purity of 97% enantiomeric excess | Homo sapiens | (R)-benzoin + NADP+ | - |
r | |
dehydrolithocholic acid + NADPH | - |
Homo sapiens | isolithocholic acid + NADP+ | - |
r | |
diacetyl + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
dimethyl-2-oxo-glutarate + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
hexanophenone + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
isatin + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
isolithocholic acid + NADP+ | - |
Homo sapiens | dehydrolithocholic acid + NADPH | - |
r | |
menadione + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
additional information | enzyme exhibits high stereo-selectivity yielding 3-beta-hydroxysteroids from 3-ketosteroids | Homo sapiens | ? | - |
? | |
n-butyrophenone + NADPH | major product | Homo sapiens | (S)-1-phenyl1-butanol + NADP+ | - |
r | |
pyridine-4-aldehyde + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r | |
testosterone + NADPH + H+ | - |
Homo sapiens | ? + NADP+ | - |
r | |
valerophenone + NADPH | - |
Homo sapiens | ? + NADP+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
DHRS4 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.014 | - |
5beta-pregnane-3beta,20alpha-diol | pH 7.4, 25°C | Homo sapiens | |
0.017 | - |
5beta-androstan-3beta-ol-17-one | pH 7.4, 25°C | Homo sapiens | |
0.017 | - |
5beta-androstane-3beta,17beta-diol | pH 7.4, 25°C | Homo sapiens | |
0.041 | - |
5beta-Pregnan-3beta-ol-20-one | pH 7.4, 25°C | Homo sapiens | |
0.043 | - |
Dehydrolithocholic acid | pH 7.4, 25°C | Homo sapiens | |
0.05 | - |
all-trans-retinal | pH 7.4, 25°C | Homo sapiens | |
0.063 | - |
5beta-pregnane-3,20-dione | pH 7.4, 25°C | Homo sapiens | |
0.07 | - |
5beta-pregnan-20alpha-ol-3-one | pH 7.4, 25°C | Homo sapiens | |
0.075 | - |
(S)-phenyl-1-butanol | pH 7.4, 25°C | Homo sapiens | |
0.077 | - |
5beta-androstane-3,17-dione | pH 7.4, 25°C | Homo sapiens | |
0.083 | - |
5beta-androstan-17beta-ol-3-one | pH 7.4, 25°C | Homo sapiens | |
0.095 | - |
5alpha-dihydrotestosterone | pH 7.4, 25°C | Homo sapiens | |
0.097 | - |
5alpha-androstane-3,17-dione | pH 7.4, 25°C | Homo sapiens | |
0.18 | - |
(S)-1-indanol | pH 7.4, 25°C | Homo sapiens | |
0.25 | - |
(S)-1-tetralol | pH 7.4, 25°C | Homo sapiens | |
0.65 | - |
menadione | pH 7.4, 25°C | Homo sapiens | |
0.85 | - |
n-butyrophenone | pH 7.4, 25°C | Homo sapiens | |
0.88 | - |
1,4-Naphthoquinone | pH 7.4, 25°C | Homo sapiens | |
2 | - |
4-benzoylpyridine | pH 7.4, 25°C | Homo sapiens | |
2 | - |
valerophenone | pH 7.4, 25°C | Homo sapiens | |
2 | - |
6-tert-butyl-2,3-epoxy-5-cyclohexene-1,4-dione | pH 7.4, 25°C | Homo sapiens | |
2.7 | - |
hexanophenone | pH 7.4, 25°C | Homo sapiens | |
3.7 | - |
4,4'-dimethylbenzil | pH 7.4, 25°C | Homo sapiens | |
4.7 | - |
Pyridine-4-aldehyde | pH 7.4, 25°C | Homo sapiens | |
11.8 | - |
9,10-phenanthrenequinone | pH 7.4, 25°C | Homo sapiens | |
16.3 | - |
2,3-Hexanedione | pH 7.4, 25°C | Homo sapiens | |
16.7 | - |
4-nitrobenzaldehyde | pH 7.4, 25°C | Homo sapiens | |
26.7 | - |
2,3-Pentanedione | pH 7.4, 25°C | Homo sapiens | |
28.3 | - |
diacetyl | pH 7.4, 25°C | Homo sapiens | |
31.7 | - |
isatin | pH 7.4, 25°C | Homo sapiens | |
31.7 | - |
benzil | pH 7.4, 25°C | Homo sapiens | |
33.3 | - |
4-hexanoylpyridine | pH 7.4, 25°C | Homo sapiens | |
33.3 | - |
dimethyl-2-oxo-glutarate | pH 7.4, 25°C | Homo sapiens | |
40.2 | - |
2,3-heptanedione | pH 7.4, 25°C | Homo sapiens | |
41.7 | - |
1-phenylisatin | pH 7.4, 25°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
dimethyl-2-oxoglutarate reductase activity | Homo sapiens |
6.5 | 10 | broad, S-1-tetralol dehydrogenase activity | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | no significant activity with NAD+/NADH | Homo sapiens | |
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0027 | - |
pH 7.4, 25°C | Homo sapiens | quercetin | |
0.0059 | - |
pH 7.4, 25°C | Homo sapiens | genistein | |
0.0066 | - |
pH 7.4, 25°C | Homo sapiens | Cetylpyridinium chloride | |
0.023 | - |
pH 7.4, 25°C | Homo sapiens | phenylhexane |