Cloned (Comment) | Organism |
---|---|
expression analysis of the enzyme in sciatic nerves | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
estradiol | 0.0005 mM, 40% inhibition, 0.001 mM, 62% inhibition | Rattus norvegicus | |
progesterone | 0.025 mM, 44% inhibition, 0.05 mM, 67% inhibition | Rattus norvegicus | |
trilostane | 0.005 mM, 56% inhibition, 0.025 mM, 90% inhibition; potent inhibition | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic analysis | Rattus norvegicus | |
0.001 | - |
pregnenolone | 37°C | Rattus norvegicus | |
0.0011 | - |
pregnenolone | 37°C | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
x * 45000, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | enzyme regulation by steroids, overview | ? | - |
? | |
pregnenolone + NAD+ | Rattus norvegicus | - |
pregn-5-en-3,20-dione + NADH + H+ | - |
? | |
pregnenolone + NAD+ | Rattus norvegicus | - |
progesterone + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus | - |
male SpragueDawley rats, type I and IV isozymes | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
sciatic nerve | - |
Rattus norvegicus | - |
sciatic nerve | expression analysis | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme regulation by steroids, overview | Rattus norvegicus | ? | - |
? | |
pregnenolone + NAD+ | - |
Rattus norvegicus | pregn-5-en-3,20-dione + NADH + H+ | - |
? | |
pregnenolone + NAD+ | - |
Rattus norvegicus | progesterone + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 45000, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
3beta-HSD | - |
Rattus norvegicus |
3beta-hydroxysteroid dehydrogenase/isomerase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Rattus norvegicus |