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Literature summary for 1.1.1.141 extracted from

  • Backlund, M.G.; Mann, J.R.; Holla, V.R.; Shi, Q.; Daikoku, T.; Dey, S.K.; DuBois, R.N.
    Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and Snail in colorectal cancer (2008), Cancer Res., 68, 9331-9337.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information treatment of colorectal cancer cells with 5-aza-2'-deoxycytidine, 5 mM sodium butyrate or 5 mM valproic acid induces an increase in 15-PGDH protein expression Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information histone deacetylase 2 and the transcriptional regulator Snail play a central role in the suppression of 15-PGDH expression Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
LS174T cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
15-PGDH
-
 Homo sapiens
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Homo sapiens