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Literature summary for 1.1.1.141 extracted from
- 15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer (2008), Cancer Res., 68, 5040-5048.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | 15-PGDH expression is increased by hepatocyte nuclear factor 3beta in lung cancer cells | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | loss of 15-hydroxyprostaglandin expression in 65% of lung cancers. Enzyme acts as a tumor suppressor in lung cancer and is a direct downstream effector of hepatocyte nuclear factor 3beta | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| Y151L/K155E | inactive | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-549 cell | - |
Homo sapiens | - |
| Calu-1 cell | - |
Homo sapiens | - |
| Calu-6 cell | - |
Homo sapiens | - |
| lung cancer cell | - |
Homo sapiens | - |
| lung cancer cell | loss of 15-hydroxyprostaglandin expression in 65% of lung cancers. Enzyme acts as a tumor suppressor in lung cancer | Homo sapiens | - |
| NCI-H125 cell | - |
Homo sapiens | - |
| NCI-H211 cell | - |
Homo sapiens | - |
| NCI-H23 cell | - |
Homo sapiens | - |
| NCI-H292 cell | - |
Homo sapiens | - |
| NCI-H322 cell | - |
Homo sapiens | - |
| NCI-H358 cell | - |
Homo sapiens | - |
| NCI-H441 cell | - |
Homo sapiens | - |
| NCI-H460 cell | - |
Homo sapiens | - |
| NCI-H661 cell | - |
Homo sapiens | - |
| NCI-H69 cell | - |
Homo sapiens | - |
| non-small cell lung cancer cell | - |
Homo sapiens | - |
| SK-LU-1 cell | - |
Homo sapiens | - |
| SK-MES-1 cell | - |
Homo sapiens | - |
| SW-900 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 15-hydroxyprostaglandin + NAD+ | - |
Homo sapiens | 15-oxoprostaglandin + NADH + H+ | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase | - |
Homo sapiens |
| 15-PGDH | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | dependent on | Homo sapiens | |
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Release 2023.1 (January 2023)
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